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was significant gas and fluid dilation of the ileum, ascending colon, and transverse colon. At the splenic flexure, there was a colonic stricture composed of severe fibrous adhesions involving the colon, omentum, and jejunum. Within the fibrosis, a
adhesions that was obstructive and precluded cervical patency. Pyometra secondary to transluminal cervical adhesions was diagnosed. The purulent material was removed from the uterus over a period of days in an effort to reduce potential contamination
equine platelets can be influenced by selective PDE inhibition, the study reported here was conducted to determine the PDE isoenzyme profile in equine platelets. An assay of platelet adhesion to serum-coated plastic was then used to examine the effects of
level, with no evidence of hyperechoic suture material. The urinary bladder was otherwise filled with a mild amount of anechoic fluid. Therefore, it was suspected that the patient’s clinical signs were caused by adhesions within the bladder lumen
Abstract
Objective—To compare laparoscopic dissection withlaparoscopic dissection combined with abdominal instillation of ferric hyaluronate gel for the treatment of experimentally induced adhesions in pony foals.
Animals—12 healthy pony foals.
Procedure—A serosal abrasion method was used to create adhesions at 4 sites on the jejunum (day 0). At day 7, laparoscopy was performed and the adhesions observed in each foal were recorded. In group-1 foals (n = 6), the adhesions were separated laparoscopically (treatment 1). In group-2 foals (n = 6), 300 mL of 0.5% ferric hyaluronate gel was infused into the abdomen after the adhesions were separated laparoscopically (treatment 2). At day 24, terminal laparoscopy was performed and the adhesions observed were recorded. Total number of adhesions within each group was compared between day 7 and 24. Data were analyzed to determine whether an association existed between the number of adhesions on day 24 and treatment type.
Results—At day 24, the number of adhesions was significantly decreased within each group, compared with the number of adhesions at day 7 (group-1 foals, 10 vs 22 adhesions; group-2 foals, 3 vs 20 adhesions). Treatment 1 was associated with a significantly higher number of adhesions at day 24, compared with treatment 2 (odds ratio, 4.54; 95% confidence interval, 1.03 to 23.02).
Conclusions and Clinical Relevance—Abdominal instillation of 0.5% ferric hyaluronate gel after laparoscopic dissection was a more effective technique than laparoscopic dissection alone to treat experimentally induced adhesions in pony foals. Laparoscopic adhesiolysis following abdominal surgery in foals is a safe and effective technique. ( Am J Vet Res 2004;65:681–686)
amounts of vitamin C (200 mg/kg of fresh berries), flavonoids, proanthocyanidins, catechins, and triterpinoids. 4,5 The E coli strains that cause UTIs have proteinaceous macromolecules (fimbriae) that facilitate adhesion of bacteria to uroepithelial
Abstract
Objective—To assess the efficacy of laparoscopic adhesiolysis in the treatment of experimentally induced adhesions in foals.
Animals—8 healthy pony foals.
Procedure—Celiotomy was performed and adhesions created at the jejunoileal junction and at sites 0.5 and 1 m proximal to this junction, using a serosal abrasion method. Ten days after celiotomy, exploratory laparoscopy was performed. Laparoscopic adhesiolysis was performed in the treatment group only (4 foals, randomly selected). Thirty days after the exploratory laparoscopy, a final laparoscopic examination was performed, and the foals were euthanatized. The number and characteristics of abdominal adhesions were recorded during laparoscopy 10 and 30 days after celiotomy and during necropsy.
Results—At 30 days after celiotomy, the number of adhesions in the control group was significantly higher than the number in the treatment group. In the control group, all adhesions observed during the exploratory laparoscopy were still evident at the final laparoscopy and necropsy. In the treatment group, adhesions did not form again after separation. During final laparoscopy and necropsy, a focal adhesion between the omentum and site of the initial laparoscope portal was observed in 5 of 8 foals.
Conclusions and Clinical Relevance—The serosal abrasion model is useful for studying abdominal adhesions in foals. Laparoscopic adhesiolysis was an effective technique to break down experimentally induced adhesions in the early maturation stage of formation in pony foals. Studies are required to investigate prevention of de novo adhesions at the laparoscope portal sites. (Am J Vet Res 2002;63:289–294)
bacterial binding. The adhesion of the bacteria to brush border vesicles can be observed via phase-contrast microscopy. By use of an in vitro microscopic brush border adhesion assay involving ETEC K88 bacteria, Sellwood et al 5 initially described 2 pig
Summary
Efficacy of a 1% solution of sodium carboxymethylcellulose (cmc) infused into the peritoneal cavity of ewes was evaluated for prevention of intraperitoneal adhesions resulting from surgery of the reproductive tract. Six ewes were assigned to each of 4 groups. Group-1 ewes were controls that underwent ventral midline celiotomy and exploration of the abdominal viscera. Group-2 ewes were treated similarly to group-1 ewes, except that a 1% solution of cmc (14 ml/kg of body weight) was infused into the peritoneal cavity. This group was studied to determine whether cmc would cause changes in the peritoneal cavity. Group-3 comprised ewes representing a uterine trauma model. Ewes underwent abdominal exploration, but in addition had a standard embryo collection technique performed on 1 uterine horn and hysterotomy performed on the opposite uterine horn. Group-4 ewes were treated like group-3 ewes, except that, similar to treatment of group-2 ewes, cmc was infused into the peritoneal cavity. All ewes were euthanatized and necropsied 12 to 14 days after surgery.
Abdominal adhesions were evaluated, and an adhesion severity score was assigned to each ewe on the basis of number and severity of the adhesions. Ewes of all groups had abdominal adhesions. Significantly (P < 0.05) lower adhesion score was observed in ewes given cmc (groups 2 and 4) than in the adhesion model (group 3). Significant difference was not observed in adhesion score when groups 1, 2, or 4 were compared. Though not statistically significant, fewer adhesions were observed in ewes of groups 2 and 4 than in group-1 ewes.
SUMMARY
Twelve ponies were used to evaluate the reliability of an abdominal adhesion model and the efficacy of intraperitoneal infusion of sodium carboxymethylcellulose in preventing abdominal adhesions. A celiotomy was performed on each of the 12 ponies and the serosa of the distal portion of the jejunum was abraded with a dry gauze sponge at 5 locations. In addition to the serosal damage, a single 2-0 chromic gut suture was placed through the seromuscular layer of the jejunum in the center of the abraded area. After closure of the celiotomy, a 1% solution of sodium carboxymethylcellulose (7 ml/kg of body weight) was infused into the peritoneal cavity of 6 ponies. The other ponies served as untreated controls. All ponies were euthanatized 14 days after surgery.
All ponies in the control group had abdominal adhesions at the time of necropsy. Four of the 6 ponies in the treatment group were free of adhesions. There was a significant (P < 0.0001) difference in the total number of adhesions between the 2 groups.
