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illness scores. Understanding the kinetics of serum vitamin D metabolites in companion animals during hospitalization may be clinically valuable. We hypothesized that vitamin D metabolites and selected acute-phase proteins (APPs) would be complementary

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in Journal of the American Veterinary Medical Association

tylosin/kg. Cottonseed meal was used as the carrier. Serum leptin concentrations were determined via procedures reported by Delavaud et al. 8 A serum amyloid-A assay l and haptoglobin assay m were used to analyze serum acute-phase proteins. To

Full access
in American Journal of Veterinary Research

Abstract

Objective—To evaluate changes in serum concentrations of acute-phase proteins in dogs with leishmaniosis during short-term therapy in accordance with 2 treatment protocols and determine whether concentrations of acute-phase proteins could be used to monitor the initial response of dogs to treatment.

Animals—12 dogs naturally infected with Leishmania infantum.

Procedure—Dogs were allocated into 2 groups. Dogs of group 1 were treated by use of meglumine antimonate (100 mg/kg, SC, q 24 h) administered concurrently with allopurinol (15 mg/kg, PO, q 12 h) for 20 days and then with allopurinol alone at the same dosage for the subsequent 30 days. Dogs of group 2 were treated by administration of allopurinol alone (15 mg/kg, PO, q 12 h) for 60 days). Blood samples were obtained before and during treatment for measurement of serum concentrations of acute-phase proteins and determination of CBC counts, serum biochemical analyses, and electropherograms.

Results—All dogs evaluated in the study had increased concentrations of C-reactive protein, haptoglobin, and ceruloplasmin at the time of diagnosis of leishmaniosis. Mean concentration of serum amyloid A before treatment was also increased, but some of the dogs had concentrations of serum amyloid A that were within the reference range. Concentrations of C-reactive protein and ceruloplasmin decreased significantly in all dogs at the end of the study period.

Conclusions and Clinical Relevance—Measurement of concentrations of selected acute-phase proteins, such as C-reactive protein or ceruloplasmin, could be used to evaluate the initial response of dogs with leishmaniosis to treatment. (Am J Vet Res 2003;64:102–1026)

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in American Journal of Veterinary Research

SUMMARY

Concentration of the acute-phase protein serum amyloid-A (saa) was measured by means of an indirect ELISA method, in plasma of 3 pregnant cows and in plasma taken by cannula from another 4 pregnant cows and, by separate cannula, from their fetuses. Blood samples were taken daily from approximately 72 hours before until 72 hours after parturition. After parturition, saa concentration increased significantly (P < 0.05) in maternal plasma. In fetal plasma, only a nonsignificant increase was found at time of delivery. The concentration of maternal saa started to increase within the first 24 hours after delivery, reaching a peak value between 24 and 48 hours after delivery.

In the aforementioned plasma samples from the 4 pregnant cows and their fetuses, the concentration of maternally derived cortisol increased nonsignificantly after parturition. The concentration of fetally derived cortisol was significantly (P< 0.05) increased at parturition (t = 0), compared with the initial fetal cortisol concentration at 120 hours before delivery.

Peripartum concentration of maternal saa increased and maternal cortisol remained low, whereas fetal saa concentration remained low and fetal cortisol concentration increased. These findings indicate possible suppressive action of fetal cortisol on fetal saa production. However, it might be argued that the main cause of the difference in saa concentration is the difference in tissue damage between cows and fetuses at parturition.

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in American Journal of Veterinary Research

can be influenced by inflammation. Because of the influence of inflammation on iron metabolism, we concurrently measured serum concentrations of the acute phase proteins CRP and ceruloplasmin in study samples. In the present study, mean ceruloplasmin

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in Journal of the American Veterinary Medical Association

with other variables, as a marker of subclinical infections in cats remains to be further investigated. ABBREVIATIONS AGP α 1 -Acid glycoprotein APP Acute-phase protein CRP C-reactive protein IAC Internal amplification control SAA

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in American Journal of Veterinary Research

Abstract

Objective—To correlate serum concentrations of fibrinogen (Fib), haptoglobin (Hap), serum amyloid-A (SAA), and α-1 acid glycoprotein (AGP) with clinical respiratory tract disease and response to treatment in transport-stressed feedlot cattle fed vitamin E-supplemented diets.

Animals—387 heifer calves (mean initial weight, 197 kg).

Procedure—Calves purchased from an order buyer were delivered to a feedlot to study the effects of dietary supplementation with 2,000 IU of vitamin E for 0, 7, 14, or 28 days after arrival. Serum or plasma Fib, Hap, SAA, and AGP concentrations were measured on days 0, 7, and 28 after arrival as well as at the time of treatment for respiratory tract disease with antimicrobial drugs and after completion of treatment.

Results—Vitamin E supplementation was associated with decreased treatment costs. In cattle that were not recognized as sick or responded positively to 1 antimicrobial treatment, serum Hap concentrations were significantly lower on days 0 and 7 than concentrations for cattle that required > 1 treatment. Serum Hap concentrations and ratios of Hap to SAA on day 0 significantly correlated with the number of antimicrobial treatments required. Serum Hap concentrations at the time of initial treatment were significantly lower for cattle that required only 1 treatment, compared with those that required > 1 treatment.

Conclusions and Clinical Relevance—Serum Hap concentrations are of potential value for use in assessing feedlot cattle that may become ill as a result of respiratory tract disease and for use in monitoring treatment efficacy. (Am J Vet Res 2002; 63:1111–1117)

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in American Journal of Veterinary Research

repair damaged tissues. One of the mechanisms involved is the production and secretion (primarily by the liver) of APPs. 1,2 Acute-phase proteins are classified as positive or negative depending on the increase or decrease in the serum concentration

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in American Journal of Veterinary Research

and infectious diseases and following elective and nonelective surgeries. 5–7 Acute-phase protein concentrations can either increase (positive APPs) or decrease (negative APPs) in response to inflammation. Positive APPs are categorized on the basis

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in Journal of the American Veterinary Medical Association

Acute-phase proteins (eg, CRP and haptoglobin) are proteins found in serum, and the concentration of APPs changes after tissue injury, infection, or trauma. 1 Analysis of APPs in pig production has become an area of increasing interest to

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in American Journal of Veterinary Research