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differentiated blasts with occasional mitosis in the red pulp and marginal zone ( Figure 3 ) . Based on these findings, acute myeloid leukemia (AML) with neutrophilic differentiation in bone marrow and spleen was diagnosed. Figure 1 Photomicrographs of

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in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

. Discussion Acute myeloid leukemia is a neoplasia of the hematopoietic system that usually arises in the bone marrow. In the absence of aggressive treatment, most types of AML have a rapid disease course with high morbidity and death rates. In animals, AML

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in Journal of the American Veterinary Medical Association

cells did not stain with diaminobenzidine histochemical staining for myeloperoxidase activity. No other cytochemical or histochemical stains were attempted. Morphologic Diagnosis and Case Summary Acute myeloid leukemia (AML) with heterophilic

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in Journal of the American Veterinary Medical Association

juxtamembrane domain, which also result in dysregulation of Kit function. 24–27 Similar juxtamembrane domain duplications and catalytic domain point mutations have been identified in Flt3 from humans with acute myeloid leukemia. 28,29 Lastly, both Kit and Flt3

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in American Journal of Veterinary Research

, the CpG island of ABCB1 was not in a hypermethylated state and expression of this gene was not silenced in most dogs, regardless of their chemotherapy sensitivity. ABBREVIATIONS AML Acute myeloid leukemia FNA Fine-needle aspiration

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in American Journal of Veterinary Research

carcinomas of lung, breast, and bladder, and in acute myeloid leukemia. 6,7,11 Canine MRP1 has been characterized via cell transfection studies that reveal 92% homology to human MRP1 and has been identified in a canine osteosarcoma cell line. 10,12 Limited

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in American Journal of Veterinary Research

, a role for lomustine in acute myeloid leukemia? Nat Rev Clin Oncol 2010 ; 7 : 619 – 621 . 24. Mayer J . Allometric scaling . In: Divers SJ , Scott SJ , eds. Mader's reptile and amphibian medicine and surgery . 3rd ed. St Louis

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in Journal of the American Veterinary Medical Association

Matinlauni I . Neutropenic fever and severe sepsis in adult acute myeloid leukemia (AML) patients receiving intensive chemotherapy: causes and consequences . Leuk Lymphoma 2008 ; 49 : 495 – 501 . 10.1080/10428190701809172 18. Northrup NC Rassnick

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in Journal of the American Veterinary Medical Association

. Philadelphia : WB Saunders Co , 1983 ; 419 – 432 . 12 Jain NC Blue JT Grindem CB , et al . Proposed criteria for classification of acute myeloid leukemias in dogs and cats . Vet Clin Pathol 199 ; 20

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in Journal of the American Veterinary Medical Association