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commercially available and provide a rapid single-point result with good sensitivity/specificity. Symmetric dimethylarginine (SDMA) is a sensitive early marker of acute and chronic renal disease in dogs and cats. 8 – 10 Since 2019, SDMA has been included in

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in American Journal of Veterinary Research

S ymmetric dimethylarginine (SDMA) is a blood biomarker used for the assessment of renal function that is validated in dogs, cats, rats, and horses and has been utilized in a wider range of species to evaluate renal health. 1 – 12 Classic

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in American Journal of Veterinary Research

(SDMA) is a product of protein metabolism resulting from the methylation of arginine protein residues, and > 90% of SDMA is excreted from the body by the kidneys, 5 , 6 making it a strong candidate for indirect assessment of kidney function and

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in Journal of the American Veterinary Medical Association

serum creatinine concentration are elevated. 10,13 A newer method of assessing renal function is measuring serum SDMA concentration. Symmetric dimethylarginine is a small-molecule byproduct of cellular catabolism recently identified as a novel kidney

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in American Journal of Veterinary Research

renal function. Moreover, some extrarenal factors, such as diet, muscle mass, and breed, are known to influence Cr. 5 , 6 Symmetric dimethylarginine (SDMA) is another kidney biomarker that also accurately reflects GFR, as it is eliminated almost

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in American Journal of Veterinary Research

biochemistry profile, including serum symmetric dimethylarginine (SDMA) concentration, urinalysis, urine protein: creatinine (UPC) ratio, and glomerular filtration rate (GFR) estimated by iohexol clearance. 23 Anesthesia Cats were fasted 12–18 hours

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in American Journal of Veterinary Research

lesion. Blood biochemistry revealed a mild increase in symmetric dimethylarginine (SDMA) concentration without associated azotemia ( Table 1 ) . Urinalysis of a sample collected via cystocentesis revealed specific gravity of 1.020, urine protein

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in Journal of the American Veterinary Medical Association

as currently recommended for IRIS CKD stages 2 to 4. This parallels the IRIS consensus statement on standard treatment for glomerulonephritis. SDMA an adjunct benchmark The conditional addition of symmetric dimethylarginine as a renal biomarker

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in Journal of the American Veterinary Medical Association

difficulty and relative expense. 10 A circulating marker of GFR, symmetric dimethylarginine (SDMA), has been advocated as more sensitive than serum creatinine for diagnosis of CKD. 10 However, the specificity and positive predictive value of serum SDMA for

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in American Journal of Veterinary Research

/dL), creatinine (0.9 mg/dL; reference range, 0.8 to 1.5 mg/dL), and SDMA a (13 μg/dL; reference range, ≤ 16 μg/dL for puppies). Cystocentesis was performed, and urinalysis revealed a urine specific gravity of 1.019 and pH of 6.5. Urine sediments included 0 to 3

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in Journal of the American Veterinary Medical Association