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immunomodulatory properties. 14 , 15 Additionally, both IL-1β and TGF-β2 licensing of equine bone marrow–derived MSCs modulates their transcriptional profile and protein expression in a way that could drive the tendon microenvironment toward tissue healing. 16

Open access
in Journal of the American Veterinary Medical Association

interleukin-1β (IL-1β), the central inflammatory cytokine in osteoarthritis, exhibit a marked decrease in aggrecan gene expression; whereas MPA treatment when combined with IL-1β exposure restored the aggrecan gene expression to that of chondrocytes maintained

Open access
in American Journal of Veterinary Research

with IL-1β causes increased proliferation, migration, and adhesion. 13 To the authors’ knowledge, no information is available on the effects of proinflammatory cytokines on ECFC function in horses. Therefore, the objective of the study reported here

Full access
in American Journal of Veterinary Research

osteoarthritis in dogs for in vitro evaluation of this inflammatory disease. 4–7 Several factors derived from chondrocytes and synoviocytes play a major role in the initiation and progression of osteoarthritis. Among them, IL-1β is considered one of the most

Full access
in American Journal of Veterinary Research

and synovium is the proinflammatory cytokine IL-1. 2,10–13 To study matrix metabolism in experimental investigations of osteoarthritis, cartilage explants or isolated chondrocytes are commonly treated with recombinant IL-1α or IL-1β. 14–16 Although

Full access
in American Journal of Veterinary Research

recombinant equine IL-1β. 12 The cytokine IL-1β is known to play a fundamental role in naturally occurring synovial inflammation. 13 The objective of the study reported here was to evaluate the effects of sequential anesthesia of the individual compartments

Full access
in American Journal of Veterinary Research

necessarily address the disease course of OA. To affect the progression of OA, cartilage catabolism needs to be inhibited. 18 , 19 Previous in vitro experiments revealed that synovial tissue or synoviocytes mitigate the catabolic effects of IL-1β on

Open access
in American Journal of Veterinary Research

if MHC class II expression is affected by the recipient. In vitro exposure of MSCs to inflammatory signals such as lipopolysaccharide or IL-1β increases production of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8). 17 It is unknown whether

Full access
in American Journal of Veterinary Research

arthritis. The study reported here was conducted to determine the effects of IL-1β and glucocorticoids on total GAG loss and aggrecanase-mediated matrix degradation in cartilage explants and to determine the effects on steady-state mRNA concentrations of

Full access
in American Journal of Veterinary Research

been evaluated by use of a cartilage explant model of inflammation. 4,5 Each constituent exerted unique effects on the formation of recombinant human IL-1β–induced PGE 2 , GAG, and NO and on chondrocyte viability in equine cartilage explants. 4,5 The

Full access
in American Journal of Veterinary Research