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loaded onto a 96-well plate based on the manufacturer's protocol. The absorbance was measured at 450 (AST and RRM2) and 570 nm, respectively, using a microplate reader (Bio-Rad). ATPase and creatine kinase activities, DNA damage, and triglyceride

Open access
in American Journal of Veterinary Research

DNA damage. Reversible genotoxicity induced by MTZ has been shown both in vitro and in vivo in cats. 5 Drug-induced genotoxicity may prevent the cell from completing a normal cell cycle, increasing the risk for recombination errors, deleterious

Open access
in American Journal of Veterinary Research

) against human TRX. Both antibodies were used for human TRX ELISA systems 15 in the present study. Reactive oxygen species cause oxidative damage to lipids, proteins, and nucleic acids in vivo. In humans, 8-OHdG is a major form of DNA damage induced by

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in American Journal of Veterinary Research

DNA integrity affects breeding efficiency and embryonic development in pigs. 32 On this basis, it is conceivable that in polytocous species, such as rabbits, insemination with semen that has a high number of DNA-damaged spermatozoa negatively affects

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in American Journal of Veterinary Research

DNA damage response pathways . Hum Mol Genet 2004 ; 13 : 1241 – 1248 . 10.1093/hmg/ddh135 21. Wang X Andreassen PR D'Andrea AD . Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin . Mol Cell Biol 2004

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in American Journal of Veterinary Research

ameliorate DNA damage, whether naturally occurring or derived clinical interventions, may retard or even reverse age-associated disease and dysfunction, although there is yet little direct experimental evidence demonstrating this in dogs or cats. 3 There is

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in American Journal of Veterinary Research

, Geurtsen W . The effect of camphorquinone (CQ) and CQ-related photosensitizers on the generation of reactive oxygen species and the production of oxidative DNA damage . Biomaterials 2005 ; 26 : 4091 – 4099 . 10.1016/j.biomaterials.2004.10.022 13

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in American Journal of Veterinary Research

infection is apoptosis. In addition to apoptosis, parvovirus infection leads to cell cycle arrest (as a result of DNA damage induced by the virus) and necrosis (by variable mechanisms depending on host species). 7 One study 8 investigating the pathogenesis

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in Journal of the American Veterinary Medical Association

radicals, hydroxyl anions, and hydrogen peroxide. Production of ROS can result in lipid peroxidation, protein oxidation, and DNA damage. 2 Oxidative stress has been linked to chronic diseases in humans, including diabetes mellitus, Alzheimer's disease

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in American Journal of Veterinary Research

cats given antioxidant supplements. 21 We did not measure markers of lipid peroxidation or DNA damage in these dogs. In laboratory Beagles, brain concentrations of malondialdehyde were higher in older (> 8 years old) dogs than in young dogs. 22 In

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in Journal of the American Veterinary Medical Association