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vaccine during the first 28 days following feedlot arrival compared with parenterally MLV BRSV-vaccinated and control calves. Bovine herpes virus 1 (BHV-1) is another important virus contributing to BRD that promotes secondary bacterial pneumonia in

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in American Journal of Veterinary Research

subclinical course (and would not be noticed under field conditions) can cause a marked, although transient, immunosuppression. 5,6 This explains why coinfections involving BVDV and other pathogens, such as rotavirus, coronavirus, 7,8 BHV-1, or bovine

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in American Journal of Veterinary Research

Respiratory disease in beef and dairy cattle has been causally associated with BHV-1 since the 1950s. 1–4 Soon after isolation of BHV-1 from clinically infected cattle in 1956, 5 modified-live 6 and inactivated 7 vaccines were developed and

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in Journal of the American Veterinary Medical Association

balanoposthitis syndrome) tracts as well as encephalitis. 1–3 Cattle with BHV1 infections of the upper respiratory tract frequently develop anorexia, fever, tachypnea, cough, and nasal discharge and lesions, which can lead to pathological alterations of the upper

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in American Journal of Veterinary Research

Infectious bovine rhinotracheitis is a clinically and economically important disease of cattle and is endemic in cattle populations throughout the world. Infectious bovine rhinotracheitis caused by BHV-1 is associated with a variety of clinical

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in Journal of the American Veterinary Medical Association

Herpesviridae (BHV-1), Paramyxoviridae (BPIV-3 and BRSV), and Flaviviridae (bovine viral diarrhea virus). Infectious bovine rhinotracheitis caused by BHV-1 is a highly contagious and infectious respiratory disease that affects all ages of cattle. This virus

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in Journal of the American Veterinary Medical Association

in 1954 but another 10 years of serial passage was required before it was safe for vaccination. 1 Similar efforts to culture and attenuate bovine herpesvirus-1 (BHV-1) resulted in the development of the first MLV vaccine for cattle during nearly the

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in American Journal of Veterinary Research

acquired immunity have been effectively stimulated by vaccination. Several modified-live and killed-virus vaccines containing the 5 major viruses that contribute to the bovine respiratory disease complex (BHV-1, BRSV, PI-3, and BVDV types 1 and 2) are

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in American Journal of Veterinary Research

in 1992. Investigators in that study 6 found that vaccination of feedlot calves with ML BHV-1 blocked the calves' serologic response to inoculation with an experimental MH vaccine. The same phenomenon was later identified in a vaccine field trial

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in American Journal of Veterinary Research
in American Journal of Veterinary Research