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Background “As the world’s population ages, overall health care has improved, yet the incidence of chronic, progressive neurodegenerative diseases has increased.” 1 Alzheimer disease (AD) is a progressive neurodegenerative disorder
Introduction Alzheimer disease is a neurodegenerative disease that causes progressive impairment of cognitive functions. The pathological mechanism of AD is not clear; however, some studies 1 , 2 show that the exposure of a brain to excess
for neurogenic hypertension and Alzheimer disease Drs. Griffett and Vinicia Biancardi joined forces to explore whether REV-ERB is a therapeutic target for neurogenic hypertension—a form of hypertension that originates in the CNS and is resistant to
cognitive dysfunction syndrome (comparable to dementia and Alzheimer disease in humans). Cognitive dysfunction is associated with more severe physical and physiologic changes in the brain and may manifest clinically as disorientation; altered social
Alzheimer's disease 1 and how the brain controls sleep. 2 Expanding the breadth of human disease models through the use of invertebrates leads me to anticipate a corresponding transition to the use of fewer mammals in some situations, with their use more
addressing memory impairment in dogs, we might uncover findings applicable to human medicine, particularly conditions like Alzheimer disease. A – Aging: Aging is a universal biological process impacting all living organisms. Research into systemic changes
–73 In addition to being applicable to a caregiver's behavior-based assessment of pain in an adult who is nonverbal as a result of Alzheimer's disease, these concepts are applicable to an owner's behavior-based assessment of chronic pain in their dog
epilepsy, Alzheimer's disease, and amyotrophic lateral sclerosis. 16–18 In a colony of Shetland Sheepdogs with familial epilepsy, all dogs had abnormal EEG activity, but some dogs had seizures and others did not. The purpose of the study reported here was
-cholesterol diet to create atherosclerosis or modifying the genome of a mouse to create Alzheimer's disease–like lesions in its brain. These scientific endeavors almost always compare the pathologic features in the test animal (animal model) to those in humans with
development of diabetes mellitus, heart disease, and even Alzheimer disease in COVID-19 patients have been raised. Endotheliitis and vasculitis underlie disease development following infection with either SARS-CoV-2 or FCoV. 1,5 From a one
