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M usculoskeletal disease is a common cause of poor performance, days lost from training, and retirement from competition in the equine athlete. Orthobiologics, including blood-derived products, such as platelet-rich plasma (PRP) and autologous

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in American Journal of Veterinary Research

Autologous protein solution (APS) and platelet-rich plasma (PRP) are 2 such autologous blood-based therapies for which there is supporting evidence for their role in reducing pain and improving the quality of healing in musculoskeletal disease (osteoarthritis

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(MSCs) and platelet-rich plasma (PRP) have gained significant popularity for the treatment of musculoskeletal diseases in horses. 3 These therapies have been hypothesized to provide disease-modifying effects including increasing strength of repair with

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in Journal of the American Veterinary Medical Association

use in humans. Platelet-rich plasma is widely used in humans, and PRP use and investigation in dogs have increased. 8–14 In turn, numerous companies are marketing PRP-concentrating systems, many of which are manufactured specifically for producing PRP

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in American Journal of Veterinary Research

combination treatment, investigators have turned to PRP. Platelet-rich plasma represents a concentrated form of multiple cytokines released from platelet A-granules at sites of tissue injury. These include, among others, platelet-derived growth factor, TGF-β1

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in American Journal of Veterinary Research

Introduction Regenerative medicine represents a broad field of therapies aimed at healing or replacing damaged tissues or organs. Platelet-rich plasma (PRP) is a biological therapy within the regenerative medicine field; it is believed to

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in Journal of the American Veterinary Medical Association

stabilization (eg, extracapsular tension sutures for joint ligament ruptures), rest, and palliative medical management. Platelet-rich plasma may also be used as an adjunctive or primary treatment, 16–18 and this would be advantageous from an economic

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in American Journal of Veterinary Research

ligament, bone, and wound healing, 15–20 and preparation of PRP with various commercially available systems for use in experimental studies 21–25 of ligament healing in animals has been described. Platelet-rich plasma is an ultraconcentrate of platelets

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in Journal of the American Veterinary Medical Association

-like growth factor-1 . FASEB J 2006 ; 20 : 2402 – 2404 . 10.1007/s12178-008-9032-5 3. Sampson S Gerhardt M Mandelbaum B . Platelet rich plasma injection grafts for musculoskeletal injuries: a review . Curr Rev Musculoskelet Med 2008 ; 1

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in American Journal of Veterinary Research

product for treatment of septic arthritis in those species would be advantageous. Platelet-rich plasma (PRP) is an autologous solution of concentrated platelets that contain anabolic and anti-inflammatory proteins or peptides. In veterinary medicine, PRP

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in American Journal of Veterinary Research