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  • Author or Editor: W. Emmett Braselton x
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Abstract

Objective—To quantify and compare intracellular magnesium concentrations (Mgi) in clinically normal dogs (control dogs) and dogs that have gastric dilatation- volvulus (GDV dogs) and to determine whether there is a difference in Mgi and serum magnesium concentrations (Mgs) between GDV dogs with and without cardiac arrhythmias.

Animals—41 control dogs and 21 GDV dogs.

Procedure—Rectus abdominis muscle specimens were obtained from control and GDV dogs for determination of Mgi. Blood samples were obtained from GDV dogs for determination of Mgs, and dogs were monitored for 48 hours for cardiac arrhythmias. Muscle specimens were frozen at –40 C, oven dried at 95 C, and digested with concentrated nitric acid. Multielemental analyses were performed by simultaneous/ sequential inductively coupled plasma-atomic emission spectroscopy with fixed-cross flow nebulization. The Mgi was standardized to sulfur content to correct for the amount of fat and fascia in the muscle specimen. Mean (± SEM) values were recorded in parts per million (ppm).

Results—There were no significant differences in Mgi between control (627 ± 11.1 ppm) and GDV (597 ± 20.5 ppm) dogs, in Mgi between GDV dogs with (590 ± 34 ppm) and without (584 ± 29 ppm) cardiac arrhythmias, and in Mgs between GDV dogs with (1.77 ± 0.26 ppm) and without (1.51 ± 0.09 ppm) cardiac arrhythmias. There was no correlation between Mgs and Mgi ( R2=0.0001).

Conclusions and Clinical Relevance—Results indicate that Mg depletion is not pathophysiologically important in dogs with GDV and does not play a role in the cardiac arrhythmias detected in these patients. (Am J Vet Res 2000;61:1415–1417)

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in American Journal of Veterinary Research

Abstract

Objective—To determine whether pharmacokinetic analysis of data derived from a single IV dose of iohexol could be used to predict creatinine clearance and evaluate simplified methods for predicting serum clearance of iohexol with data derived from 2 or 3 blood samples in clinically normal foals.

Animals—10 healthy foals.

Procedure—Serum disposition of iohexol and exogenous creatinine clearance was determined simultaneously in each foal (5 males and 5 females). A 3-compartment model of iohexol serum disposition was selected via standard methods. Iohexol clearance calculated from the model was compared with creatinine clearance. Separate limited-sample models were created with various combinations of sample times from the terminal slope of the plasma versus time profile for iohexol. Correction factors were determined for the limited-sample models, and iohexol clearance calculated via each method was compared with exogenous creatinine clearance by use of method comparison techniques.

Results—Mean exogenous creatinine clearance was 2.17 mL/min/kg. The disposition of iohexol was best described by a 3-compartment open model. Mean clearance value for iohexol was 2.15 mL/min/kg and was not significantly different from mean creatinine clearance. A method for predicting serum iohexol clearance based on a 2-sample protocol (3- and 4-hour samples) was developed.

Conclusions and Clinical Relevance—Iohexol clearance can be used to predict exogenous creatinine clearance and can be determined from 2 blood samples taken after IV injection of iohexol. Appropriate correction factors for adult horses and horses with abnormal glomerular filtration rate need to be determined. (Am J Vet Res 2003;64:1486–1490)

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in American Journal of Veterinary Research