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Abstract

Objective

To evaluate benign familial hyperphosphatasemia involving serum alkaline phosphatase (SAP) in pups.

Design

Pups with markedly increased SAP activity were evaluated and compared with unaffected siblings, and with other unaffected Siberian Husky pups from the same colony.

Animals

8 related litters of Siberian Husky pups (n = 56).

Procedure

At ages 11 and 16 weeks, pups were given physical examinations and blood was obtained for hematologic and serum biochemical analyses (including electrolytes and isoenzymes of alkaline phosphatase), ionized calcium concentration, and serum parathyroid hormone concentration. Diet, growth and health performance, skeletal radiographs, and genealogical data also were evaluated.

Results

Of 42 pups tested, 17 had markedly high total SAP values. Mean total SAP activity of affected pups at ages 11 and 16 weeks was over 5 times greater than mean total SAP activity of unaffected siblings and other unaffected Siberian Husky pups of the same age (P <0.001). Clinical, radiologic, and biochemical evaluation of the subjects revealed no other abnormal findings. The source of the increased SAP activity was characterized in 5 affected pups as bone isoenzyme. The mode of inheritance could not be deduced from the data, but the trait clearly is familial and autosomal.

Conclusion

The condition described in the family of Siberian Huskies bears similarity to human benign, persistent, familial hyperphosphatasemia.

Clinical Relevance

Benign familial hyperphosphatasemia should be considered in the differential diagnosis of markedly increased SAP activity in young dogs. (Am J Vet Res 1996; 57:612–617)

Free access
in American Journal of Veterinary Research

Objective

To determine whether physical examination, laboratory, or radiographic abnormalities in foals with Rhodococcus equi infection were associated with survival, ability to race at least once after recovery, or, for foals that survived and went on to race, subsequent racing performance.

Design

Retrospective study.

Animals

49 Thoroughbreds and 66 Standardbreds admitted to 1 of 6 veterinary teaching hospitals between 1984 and 1992 in which R equi infection was positively diagnosed.

Procedure

Results of physical examination, laboratory testing, and thoracic radiography were reviewed. Indices of racing performance were obtained for foals that recovered and eventually raced and compared with values for the US racing population.

Results

83 (72%) foals survived. Foals that did not survive were more likely to have extreme tachycardia (heart rate > 100 beats/min), be in respiratory distress, and have severe radiographic abnormalities on thoracic radiographs at the time of initial examination than were foals that survived. Clinicopathologic abnormalities were not associated with whether foals did or did not survive. Forty-five of the 83 surviving foals (54%) eventually raced at least once, but none of the factors examined was associated with whether foals went on to race. Racing performance of foals that raced as adults was not significantly different from that of the US racing population.

Clinical Implications

R equi infection in foals is associated with a decreased chance of racing as an adult; however, foals that eventually go on to race perform comparably to the US racing population. (J Am Vet Med Assoc 1998;213:510-515)

Free access
in Journal of the American Veterinary Medical Association