Objective—To investigate the effects of administration
of acepromazine on IV glucose tolerance tests
(IVGTTs) in dogs.
Animals—8 male mixed-breed dogs.
Procedure—With a 1-week interval between tests,
each dog underwent (in random order) an IVGTT with
or without pretest administration of acepromazine
maleate (0.1 mg/kg, SC, 30 minutes prior to the start
of the IVGTT). Food was withheld from the dogs for
14 hours prior to each test. Blood samples were
obtained at 20, 10, and 1 minute prior to and at 2, 3,
4, 5, 6, 8, 10, 12, 14, 16, 19, 22, 25, 30, 40, 50, 60, 70,
80, 90, 100, 120, 140, 160, and 180 minutes after
administration of glucose.
Results—There were no significant differences in the
baseline (ie, after food was withheld) plasma glucose,
lactate, and insulin concentrations between dogs
undergoing the IVGTT and acepromazine-IVGTT; however,
lower baseline free fatty acid concentration was
observed in acepromazine-treated dogs. Analysis of
data via the application of Bergman's minimal model of
glucose kinetics revealed no differences in insulin sensitivity,
acute insulin response to glucose, disposition
index, or glucose effectiveness between dogs treated
or not treated with acepromazine before testing.
Conclusions and Clinical Relevance—Results indicated
that in dogs undergoing IV glucose tolerance
testing, pretest administration of small doses of acepromazine
can be used as a means of chemical
restraint without interfering with results of the glucose
metabolism assessment. (Am J Vet Res