Objective—To determine long-term (> 6 months) outcome
of dogs with paraplegia and loss of hind limb
deep pain perception (DPP) resulting from intervertebral
disk herniation or trauma.
Procedure—Outcome was determined as successful
or unsuccessful. The association of neuroanatomic
localization, breed, age, weight, sex, and (for dogs
with intervertebral disk herniation) speed of onset of
signs and duration of paraplegia prior to surgery with
outcome was evaluated. Owners were contacted by
telephone to identify long-term health problems.
Results—Nine of 17 dogs with traumatic injuries
were treated, and 2 regained the ability to walk;
none of the 17 dogs regained DPP. Sixty-four of 70
dogs with intervertebral disk herniation underwent
surgery; 9 (14%) were euthanatized within 3 weeks
after surgery (7 because of ascending myelomalacia),
37 (58%) regained DPP and the ability to walk,
7 (11%) regained the ability to walk without regaining
DPP, and 11 (17%) remained paraplegic without
DPP. Outcome was not associated with any of the
factors evaluated, but speed of recovery of ambulation
was significantly associated with body weight
and age. Fifteen (41%) and 12 (32%) dogs that
regained DPP had intermittent fecal and urinary
Conclusions and Clinical Relevance—Results suggested
that the prognosis for paraplegic dogs without
DPP because of trauma was guarded, while dogs
with disk herniation had a better chance of recovering
motor function. A third of the dogs that recovered
motor function had intermittent incontinence.
Persistent loss of DPP did not preclude recovery of
motor function, but such dogs remained incontinent.
(J Am Vet Med Assoc 2003;222:762–769)
Objective—To evaluate perinuclear anti-neutrophilic cytoplasmic autoantibody (pANCA) status in Soft Coated Wheaten Terriers (SCWTs) and SCWT-Beagle crossbred dogs and to correlate pANCA status of dogs with clinicopathologic variables of protein-losing enteropathy (PLE), protein-losing nephropathy (PLN), or both.
Animals—13 SCWTs and 8 SCWT-Beagle crossbred dogs in a research colony and a control group comprising 7 dogs with X-linked hereditary nephropathy and 12 healthy SCWTs > 9 years old.
Procedures—Samples were obtained from dogs in the research colony every 6 months. At each sample-collection time point, serum concentrations of albumin, globulin, creatinine, and urea nitrogen; fecal concentration of α-proteinase inhibitor; and urinary protein-to-creatinine ratios were determined and correlated with pANCA status.
Results—20 of 21 dogs in the research colony had positive results for pANCAs at a minimum of 2 time points, and 18 of 21 dogs had definitive evidence of disease. None of the control dogs had positive results for pANCAs. A positive result for pANCAs was significantly associated with hypoalbuminemia, and pANCAs preceded the onset of hypoalbuminemia on an average of 2.4 years. Sensitivity and specificity for use of pANCAs to predict development of PLE or PLN were 0.95 (95% confidence interval, 0.72 to 1.00) and 0.8 (95% confidence interval, 0.51 to 0.95), respectively.
Conclusions and Clinical Relevance—Most dogs in this study affected with PLE, PLN, or both had positive results for pANCAs before clinicopathologic evidence of disease was detected. Thus, pANCAs may be useful as an early noninvasive test of disease in SCWTs.