Objective—To determine whether dogs with naturally
occurring canine parvoviral (CPV) enteritis have laboratory
evidence of hypercoagulability.
Animals—9 dogs with naturally occurring CPV enteritis
and 9 age-matched control dogs.
Procedure—Blood was collected from all dogs within
24 hours of admission for thromboelastography (TEG)
and determination of activated partial thromboplastin
time (aPTT), prothrombin time (PT), antithrombin III
(AT) activity, and fibrinogen concentration. Fibrin-fibrinogen
degradation product (FDP) concentration, Ddimer
concentration, and platelet count were obtained
in dogs with CPV enteritis only. Records were
reviewed for evidence of thrombosis or phlebitis.
Results—All 9 dogs with CPV enteritis had evidence
of hypercoagulability, determined on the basis of significantly
increased TEG maximum amplitude and
decreased AT activity. Fibrinogen concentration was
significantly higher in dogs with CPV enteritis than in
control dogs. The aPTT was moderately prolonged in
dogs with CPV enteritis, and FDP concentration was
< 5 mg/ml in 7 of 9 dogs. No dogs had a measurable
D-dimer concentration. Platelet counts were within
reference range. Four of 9 dogs had clinical evidence
of venous thrombosis or phlebitis associated with
catheters. One dog had multifocal splenic thrombosis
identified at necropsy.
Conclusions and Clinical Relevance—Dogs with
CPV enteritis have a high prevalence of clinical thrombosis
or phlebitis and laboratory evidence of hypercoagulability
without disseminated intravascular coagulopathy.
Thromboelastography may help identify
hypercoagulable states in dogs. (J Am Vet Med Assoc