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Abstract

Objective—To evaluate long-term success of endoscopic injection of collagen into the urethral submucosa in female dogs with urinary incontinence caused by urethral sphincter incompetence.

Design—Retrospective study.

Animals—40 incontinent female dogs.

Procedure—Medical records were reviewed for outcome and other results for dogs in which a cystoscope was passed into the urethra for deposition of 3 collagen deposits into the submucosa.

Results—27 (68%) dogs were continent for 1 to 64 months (mean, 17 months) after the collagen injection. In another 10 dogs, incontinence improved and in 6 of these dogs, full continence was regained with administration of additional medication. In 3 dogs, incontinence was unchanged. As long as 12 months after injection, there was a deterioration in the initial result in 16 dogs, after which their condition stabilized. Mild and transient adverse effects developed in 6 (15%) dogs.

Conclusions and Clinical Relevance—Long-term success of endoscopic injection of collagen was satisfactory. Relapse of incontinence might be caused by flattening of the collagen deposits rather than resorption of the collagen. (J Am Vet Med Assoc 2005;226:73–76)

Full access
in Journal of the American Veterinary Medical Association

Summary

Urethral pressures profiles (upp) obtained by use of microtransducer catheters were determined in 8 anestrous sexually intact female Beagles during general anesthesia. A upp study consisted of 3 consecutive recordings, and 4 upp studies were repeated at an interval of 5 days in each dog. Maximal urethral pressure (cm of H2O), bladder pressure (cm of H2O), and anatomic urethral length (cm) were recorded. Maximal urethral closure pressure (cm of H2O) was calculated.

Mean ± sd (for all measurements) maximal urethral closure pressure was 12.8 ± 5.6 cm of H2O (range, 2.4 to 25.2 cm of H2O). Maximal urethral closure pressure was significantly (P < 0.05) decreased during the first recording period (11.4 ± 5.8 cm of H2O), compared with the second (13.0 ± 5.2 cm of H2O) or third (14.1 ± 5.7 cm of H2O) recording periods within a upp study (3 consecutive recordings). Mean maximal difference in urethral closure pressure during a single upp study was 4.8 ± 2.4 cm of H2O. Significant difference in maximal urethral closure pressure was not observed between studies.

Mean (for all measurements) anatomic urethral length was 6.2 ± 0.9 cm (4.1 to 7.8 cm). Anatomic urethral length was significantly (P < 0.05) less during the first recording period (6.1 ± 0.9 cm), compared with values for the second and third periods (6.3 ± 0.9cm, 6.4 ± 0.9 cm respectively). Anatomic urethral length for time 3 was significantly (P < 0.05) less than the value for time 1 (5.8 ± 0.7 cm vs 6.6 ± 0.8 cm).

We conclude that the microtransducer catheter technique for measurement of upp was reproducible during a single study and between successive studies.

This method is useful in documenting maximal urethral pressure, maximal urethral closure pressure, and anatomic urethral length in clinically normal sexually intact female dogs.

Free access
in American Journal of Veterinary Research