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  • Author or Editor: Susan L. Frenier x
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Urethral smooth muscle tone in response to treatment with phenylephrine, a selective α1-adrenergic receptor agonist, and prazosin a selective α1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 μg/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 μg/kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.

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in American Journal of Veterinary Research