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History

A 7-month-old 1.3-kg (2.87-lb) sexually intact male Poodle was referred to the Veterinary Medical Teaching Hospital of Seoul National University for evaluation and treatment of microhepatica. The patient had a history of anorexia, weakness, and growth retardation and exhibited signs of hypoglycemic shock and blindness during examination by the referring veterinarian. Considering the patient's history and clinical signs, a portosystemic shunt was suspected, and CT was planned to confirm this diagnosis. On referral, results of a complete physical examination and thoracic radiography were unremarkable. A CBC and serum biochemical analysis indicated leukocytosis (20,310 cells/μL; reference range, 5,200 to 17,000

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate the effects of thiopental, propofol, and etomidate on glomerular filtration rate (GFR) measured by the use of dynamic computed tomography in dogs.

Animals—17 healthy Beagles.

Procedures—Dogs were randomly assigned to receive 2 mg of etomidate/kg (n = 5), 6 mg of propofol/kg (7), or 15 mg of thiopental/kg (5) during induction of anesthesia; anesthesia was subsequently maintained by isoflurane evaporated in 100% oxygen. A 1 mL/kg dosage of a 300 mg/mL solution of iohexol was administered at a rate of 3 mL/s during GFR measurement. Regions of interest of the right kidney were manually drawn to exclude vessels and fatty tissues and highlight the abdominal portion of the aorta. Iohexol clearance per unit volume of the kidney was calculated by use of Patlak plot analysis.

Results—Mean ± SD weight-adjusted GFR of the right kidney after induction of anesthesia with thiopental, propofol, and etomidate was 2.04 ± 0.36 mL/min/kg, 2.06 ± 0.29 mL/min/kg, and 2.14 ± 0.43 mL/min/kg, respectively. However, no significant differences in weight-adjusted GFR were detected among the treatment groups.

Conclusions and Clinical Relevance—Results obtained for the measurement of GFR in anesthetized dogs after anesthetic induction with etomidate, propofol, or thiopental and maintenance with isoflurane did not differ significantly. Therefore, etomidate, propofol, or thiopental can be used in anesthesia-induction protocols that involve the use of isoflurane for maintenance of anesthesia without adversely affecting GFR measurements obtained by the use of dynamic computed tomography in dogs.

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in American Journal of Veterinary Research