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- Author or Editor: Steven L. Berry x
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Abstract
Objective—To compare efficacy of a topically administered nonantimicrobial cream with that of lincomycin for treatment of digital dermatitis in dairy cattle.
Design—Randomized clinical trial.
Animals—98 cows from a commercial Holstein dairy herd.
Procedure—Cows with active lesions of digital dermatitis identified on a single observation day were randomly assigned to receive a nonantimicrobial cream, lincomycin paste, or no treatment. Cows were examined approximately every 4 weeks for 130 days after treatment for lesion maturity score, score for signs of pain, lesion size, and lesion activity.
Results—29 days after a single treatment, both treated groups had significantly reduced scores for signs of pain, lesion activity, lesion size, and the decision to retreat, compared with findings in the untreated group. Efficacy of the 2 treatments was not significantly different for decreasing pain score or lesion activity or for increasing lesion maturity score, but lincomycin was significantly more efficacious in decreasing lesion size and avoiding retreatment. By use of multivariate logistic regression, lactation number was a significant treatment effect modifier on the outcome of a healed lesion after treatment. Cows with ≥ 3 lactations were more likely to have a healed lesion at 29 days, compared with first- and secondlactation cows.
Conclusions and Clinical Relevance—Because antimicrobial treatments for digital dermatitis in cows require a veterinarian's prescription, the nonantimicrobial cream could serve as a viable but less consistently effective alternative to antimicrobials and could be applied by veterinarians, hoof trimmers, and others. (J Am Vet Med Assoc 2001;219:1435–1438)
Abstract
Objective—To compare the effectiveness of lincomycin and oxytetracycline for treatment of digital dermatitis (DD) in dairy cows through gross visual examination, histologic evaluation, and bacteriologic evaluation.
Design—Randomized controlled clinical trial.
Animals—25 cows with DD lesions from a commercial Holstein dairy herd.
Procedures—Cows with DD lesions were randomly assigned to 1 of 3 groups: topical treatment with 10 g of lincomycin hydrochloride (n = 11), topical treatment with 10 g of oxytetracycline hydrochloride (11), and no treatment (3) on days 1 and 2 (d1). Biopsy specimens were obtained for histologic examination from DD lesions prior to treatment and 28 or 31 days (d30) after treatment for histologic examination. Cows were clinically examined on d1, days 12 or 14 (d14), and d30.
Results—No difference was evident in clinical responses to lincomycin and oxytetracycline, so data were pooled; at d30, 8 of 11 of lincomycin-treated lesions and 7 of 11 oxytetracycline-treated lesions appeared visually healed, respectively. Gross visual examination suggested 73% (16/22) of treated cows were healed at d14 and 68% (15/22) of treated cows were healed on d30. Of the 15 lesions that appeared healed on d30, 7 of 15 were classified histologically as active (ulceration and bacterial invasion; 2/15) or incipient (5/15).
Conclusions and Clinical Relevance—Clinical responses to lincomycin and oxytetracycline did not differ. Agreement was good between gross visual and histologic assessments of DD lesions before treatment; agreement 1 month after treatment was variable. Histologic evaluation could not distinguish incomplete healing from lesion recurrence.
