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  • Author or Editor: Shigeyoshi Nagasawa x
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Summary

Changes in serum alpha1-acid glycoprotein (α1 AG) concentration in cattle with hepatic abscesses were observed, and function of α1 ag was evaluated, particularly its influence on cellular immune response. Test cattle (n = 4) were inoculated with Fusobacterium necrophorum, control cattle (n = 2) were inoculated with inactivated bacteria, and naturally affected cattle (n = 11) were found in a slaughterhouse.

Determination of α1 ag was made by use of a single radial immunodiffusion method. The action on lymphocyte blastogenesis was determined by [3H]thymidine incorporation. Cultured lymphocytes from healthy cattle were treated with variable concentrations of α1 ag purified from serum obtained from cattle with hepatic abscesses and suppression of blastogenesis stimulated by each of 3 mitogens was measured.

In cattle with experimentally induced abscesses, serum α1 ag concentration increased for 7 to 10 days after F necrophorum inoculation, its change being parallel to that of sialic acid. High concentration of α1 ag was found in naturally affected cattle and was highly correlated to sialic acid concentration. Suppression of lymphocyte blastogenesis in cattle with experimentally induced hepatic abscesses was highly correlated to serum α1 ag concentration.

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in American Journal of Veterinary Research