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  • Author or Editor: Seiichi Ohashi x
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Heparin inhibited hemagglutination (ha) by pseudorabies virus (prv), but not ha by Akabane virus, bovine adenovirus type 7, Fukuoka virus, Getah virus, Japanese encephalitis virus, and parainfluenza virus type 3 belonging to the families Bunyaviridae, Adenoviridae, Rhabdoviridae, Togaviridae, Flaviviidae, and Paramyxoviridae, respectively. The minimal inhibitory concentration of heparin required to inhibit 8 ha U of prv ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the ha inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by prv. Virus-heparin complex formation could be observed by sedimenting heparin with the virus particles.

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in American Journal of Veterinary Research