Objective—To describe the use of hydropulsion with sterile isotonic buffered ophthalmic solution (ie, eyewash) for the treatment of superficial corneal foreign bodies in veterinary patients and evaluate signalment, clinical findings, and outcomes following the procedure.
Design—Retrospective case series.
Animals—11 dogs, 2 cats, and 2 horses.
Procedures—Medical records were retrospectively reviewed to identify patients that underwent hydropulsion treatment for a superficial, nonpenetrating corneal foreign body confirmed by ophthalmic examination. Data regarding signalment, reason for evaluation, ocular diagnoses, and treatment were recorded. Hydropulsion was performed with a 6-mL syringe filled with eyewash solution and a 25-gauge needle with the needle tip removed. Owners and referring veterinarians of patients that did not have a recheck examination recorded were contacted by telephone for follow-up information.
Results—The corneal foreign body was an incidental finding in 3 of 15 patients. The most common clinical signs included blepharospasm, conjunctival hyperemia, and corneal vascularization. Hydropulsion was successful for foreign body removal in all 15 cases. No complications were observed during or following the procedure. In the 9 patients that had a follow-up examination, the cornea tested negative for retention of topically applied fluorescein (with a mean of 6.3 days from treatment to follow-up). At the time of last follow-up examination or telephone follow-up, no patients were reported to have clinical signs of ocular discomfort or corneal opacity associated with the affected site.
Conclusions and Clinical Relevance—In these patients, hydropulsion was easily performed with readily available materials and was successful for the removal of superficial corneal foreign bodies with no adverse effects.
OBJECTIVE To determine tear film concentrations of doxycycline in ophthalmologically normal dogs following oral doxycycline administration.
DESIGN Crossover study.
ANIMALS 10 privately owned dolichocephalic or mesaticephalic dogs free of ophthalmic disease.
PROCEDURES Dogs were randomly assigned to receive doxycycline hyclate first at 5 mg/kg (2.3 mg/lb) or 10 mg/kg (4.5 mg/lb), PO, every 12 hours for 5 days, beginning on day 1. Doxycycline was administered 1 hour prior to feeding. Tear samples were collected from days 1 through 10 approximately 3 hours after the morning dose was administered. Following a 3-week washout period, dogs received the alternative dose in the same conditions. Doxycycline concentration in tear samples from 1 eye (same eye used for both sessions) was measured via liquid chromatography–mass spectrometry and compared between the 2 doxycycline doses.
RESULTS Doxycycline was detected in tear samples of all dogs from days 1 through 10 for both doxycycline doses. Median peak doxycycline concentrations for the 5 mg/kg and 10 mg/kg doses were 2.19 ng/mL on day 3 and 4.32 ng/mL on day 4, respectively. Concentrations differed significantly with time, but this difference was not influenced by dose, dose order, or eye. A significant positive correlation was identified between doxycycline concentration and body weight (r = 0.22).
CONCLUSIONS AND CLINICAL RELEVANCE Detectable doxycycline concentrations were achieved in the tear film of ophthalmologically normal dogs following oral administration of doxycycline at 5 or 10 mg/kg, every 12 hours. Dose had no significant effect on tear film concentration of the drug.