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A 10-year-old neutered male Mastiff-cross dog was presented to the Western College of Veterinary Medicine, Veterinary Medical Centre, University of Saskatchewan, for weight loss despite increased appetite of an unknown duration. The dog had no other clinical concerns other than a previously diagnosed coxofemoral osteoarthritis that was being managed with pentosan polysulfate sodium (3 mg/kg, SC, weekly for 4 weeks) and meloxicam (0.1 mg/kg, PO, q 24 h), as needed.

Clinical and Clinicopathologic Findings

On physical examination, the dog was slightly hyperthermic (39.5 °C) and panting and had wasting of the epaxial and hind limb musculature. A

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in Journal of the American Veterinary Medical Association