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  • Author or Editor: Sandra M. Nijmeijer x
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Summary

The influence of infection with Ehrlichia phagocytophila (ep) on serum thyroid hormone concentrations and on antipyrine (25 mg/kg of body weight, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. Mean thyroid hormone concentrations moderately decreased in ep-infected goats, with maximal decrease in total and free triiodothyronine and thyroxine serum concentrations of 56, 64, 23, and 19%, respectively. The estimated pharmacokinetic values of antipyrine (ap) in ep-infected goats were similar to those in the goats when healthy. However, glucuronidation of the ap-metabolites 3-hydroxymethyl-ap, 4,4′-dihydroxy-ap, and 4-hydroxy-ap was reduced during the febrile episode of the acute-phase response to ep infection.

Free access
in American Journal of Veterinary Research

Summary

The influence of triiodothyronine (5 μg/kg of body weight, sc, q 12 h for 7 days) on antipyrine (ap, 25 mg/kg, iv) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. After triiodothyronine treatment, a significant increase in ap elimination was found. However, the observed changes in clearances for production of ap metabolites (nor-ap, 3-hydroxymethyl-ap; 4-hydroxy-ap, and 4,4′-dihydroxy-ap) do not suggest a clear selectivity of triiodothyronine toward any of the metabolic pathways of ap.

Free access
in American Journal of Veterinary Research