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Objective—To evaluate effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing general anesthesia for fracture repair.
Animals—26 client-owned dogs.
Procedure—Anesthesia was induced with levomethadone, diazepam, and propofol and maintained by administration of isoflurane in oxygen-nitrous oxide. Carprofen (4 mg/kg, SC) was administered 1 hour before induction to 13 dogs (group 1) and after extubation to the other 13 dogs (group 2). All dogs also received carprofen (4 mg/kg, SC, q 24 h) for the first 4 days after surgery. Renal function (glomerular filtration rate [GFR], urinary protein-to-urinary creatinine ratio [UP:UC], and results of urinalysis and biochemical analysis of plasma), hemostatic variables (bleeding time, platelet aggregation, prothrombin time [PT], activated partial thromboplastin time [APTT], and platelet count), and Hct were assessed before and at various time points after surgery.
Results—Analysis of results for renal function tests, most of the hemostatic and plasma biochemical variables, and Hct did not reveal significant differences between treatment groups. Values for GFR, UP:UC, PT, APTT, and platelet aggregation were outside reference ranges in many dogs before surgery and during the first 6 hours after surgery. In most dogs, these trauma-induced pathologic changes returned to within reference ranges during the 4-day period after surgery.
Conclusions and Clinical Relevance—Carprofen did not cause clinically relevant adverse effects in dogs anesthetized for fracture repair after 5 days of treatment, even when it was administered before surgery or given to patients with trauma-induced alterations in renal function or hemostasis. (Am J Vet Res 2005;66:1356–1363)
Objective—To determine the accuracy of ultrasonography in detecting fragmentation of the medial coronoid process (FMCP) in dogs.
Animals—102 dogs (112 elbow joints) suspected to have FMCP.
Procedures—Elbows were examined ultrasonographically prior to surgery for evidence of fragmentation, fissuring, or deformation of the medial coronoid process; thickening of the joint capsule; joint effusion; and secondary new bone formation. Results were compared with intraoperative findings.
Results—At surgery, 51 (46%) joints had free fragments, 55 (49%) had nondisplaced fragments, and 6 (5%) did not have any fragments or fissures. Fragments were not seen ultrasonographically in 23 of the 51 (45%) joints in which a free fragment was found during surgery or in 50 of the 55 (91%) joints in which a nondisplaced fragment was found during surgery. Accuracy of using ultrasonographic evidence of any medial coronoid process abnormality (ie, a medial coronoid process fragment, deformation of the medial coronoid process, or both) for diagnosis of medial coronoid process fragmentation was 77%. The kappa coefficient for the level of agreement between ultrasonographic (ie, any medial coro-noid process abnormality) and surgical findings was −0.014, indicating that there was no agreement.
Conclusions and Clinical Relevance—Results suggested that ultrasonography was of limited diagnostic value in detecting FMCP in dogs.