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  • Author or Editor: Sabine C. Riesen x
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A 9-year-old spayed female Doberman Pinscher was referred to the small animal clinic of the University of Berne because of severe apathy, weakness, anorexia, and diarrhea of 4 days' duration. On physical examination (day 0), the dog's weight was considered normal (27 kg [59.4 lb]). Heart rate, respiratory rate, and rectal temperature were within reference limits. The dog was dehydrated (estimated to be 8%). Mucous membranes were pink and dry, and the capillary refill time was prolonged (> 2 seconds). On initial auscultation, the dog had a regular cardiac rhythm with a heart rate of 110 beats/min. A grade 2/6

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in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate the effects of the pacemaker funny current (If) inhibitor ivabradine on heart rate (HR), left ventricular (LV) systolic and diastolic function, and left atrial performance in healthy cats and cats with hypertrophic cardiomyopathy (HCM).

Animals—6 healthy cats and 6 cats with subclinical HCM.

Procedures—Anesthetized cats underwent cardiac catheterization and were studied over a range of hemodynamic states induced by treatment with esmolol (200 to 400 μg/kg/min, IV), esmolol and dobutamine (5 μg/kg/min, IV), ivabradine (0.3 mg/kg, IV), and ivabradine and dobutamine. Left ventricular systolic and diastolic function, cardiac output, and left atrial function were studied via catheter-based methods and echocardiography.

Results—Treatment with ivabradine resulted in a significant reduction of HR, rate-pressure product, and LV contractile function and a significant increase in LV end-diastolic pressure, LV end-diastolic wall stress, and LV relaxation time constant (tau) in cats with HCM. Concurrent administration of ivabradine and dobutamine resulted in a significant increase of LV contractility and lusitropy, with blunted chronotropic effects of the catecholamine. Left atrial performance was not significantly altered by ivabradine in cats with HCM. Regression analysis revealed an association between maximum rate of LV pressure rise and tau in cats with HCM.

Conclusions and Clinical Relevance—Ivabradine had significant effects on several cardiovascular variables in anesthetized cats with HCM. Studies in awake cats with HCM are needed to clinically validate these findings.

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in American Journal of Veterinary Research