Objective—To determine prevalence of splenic hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion and to identify factors that could differentiate between dogs with hemangiosarcoma and dogs with other splenic masses at the time of hospital admission.
Design—Retrospective case series.
Procedures—Medical records, blood bank logs, and histologic reports of dogs with a splenic mass and hemoperitoneum that required a transfusion between 2003 and 2005 were reviewed. Dogs that received a transfusion of packed RBCs, were splenectomized, and had a definitive histologic diagnosis were included.
Results—Signalment of dogs was similar to that in other reports. Malignant splenic neoplasia was identified in 54 of 71 (76.1%) dogs, whereas 17 of 71 (23.9%) dogs had a benign splenic lesion. Of 54 dogs with malignant splenic neoplasia, 50 (92.6% [70.4% of all dogs]) had splenic hemangiosarcoma. In addition, dogs with splenic hemangiosarcoma had significantly lower total solids (TS) concentrations and platelet counts at admission. Finally, hemoperitoneum was strongly associated with a diagnosis of splenic hemangiosarcoma.
Conclusions and Clinical Relevance—In this clinical population of dogs, prevalence of hemangiosarcoma was higher than in other studies. Dogs with hemangiosarcoma in this study had significantly lower TS concentrations and platelet counts at the time of admission, compared with values for dogs with other splenic masses. No other markers were useful in differentiating dogs with hemangiosarcoma. It is important to discuss the prevalence of and poor prognosis associated with hemangiosarcoma with owners when they are contemplating whether to proceed with treatment.
Objective—To determine plasma malondialdehyde
(MDA) and serum vitamin E concentrations in dogs
with immune-mediated hemolytic anemia (IMHA) and
healthy control dogs.
Sample Population—Serum and plasma samples
from 36 dogs with IMHA and 40 healthy control dogs.
Procedure—Blood samples were collected from all
study dogs. Plasma MDA concentrations were measured
by use of a commercial colorimetric assay, and
serum vitamin E concentrations (α-, γ-, and δ-tocopherol
concentrations) were measured via high-performance
Results—Plasma MDA concentrations were significantly
higher in the dogs with IMHA than in the control
dogs. Compared with control dogs, serum α-, γ-,
and δ-tocopherol concentrations were significantly
lower in the IMHA-affected dogs.
Conclusions and Clinical Relevance—Results indicated
a state of oxidative stress and reduced antioxidant
reserve in dogs with IMHA; this finding provides
support for further investigation of the potential benefits
of antioxidant treatment in dogs with this disease.
(Am J Vet Res 2004;65:1621–1624)