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  • Author or Editor: Russ L. Stickle x
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SUMMARY

The blood supply to the proximal sesamoid bone of the equine forelimb was examined in 18 cadaver limbs from adult horses, using x-ray computed tomography and a tissue-clearing (Spalteholz) technique. Results of the study indicated that the proximal sesamoid bones were supplied by multiple branches of the medial and lateral palmar digital arteries, which entered the proximal half of the bones on their non-articular, abaxial surface. After entering the bone, the vessels traverse dorsally, axially, and distally, arborizing into several smaller branches that appear to supply the entire bone. The major branches of these vessels reside in bony canals, the orientation and distribution of which parallel the radiographic lucencies seen in horses with sesamoiditis and correspond to the configuration of apical fracture patterns.

Free access
in American Journal of Veterinary Research
in Journal of the American Veterinary Medical Association

Summary

We measured glomerular filtration rate (gfr) estimated by plasma disappearance of 99mTc-labeled diethylenetriaminepentaacetic acid, serum concentrations of thyroxine (T4), creatinine, and urea nitrogen, and urine specific gravity in 13 cats with naturally acquired hyperthyroidism before and 30 days after treatment by bilateral thyroidectomy, and in a group of 11 control cats. Mean (±sd) serum T4 concentration decreased from a pretreatment value of 120.46 (± 39.21) nmol/L to a posttreatment value of 12.15 (± 6.26) nmol/L (P < 0.0001; reference range, 10 to 48 nmol/L). Treatment of hyperthyroidism resulted in a decrease in mean (± sd) glomerular filtration rate, from 2.51 (± 0.69) ml/kg of body weight/min to a posttreatment value of 1.40 (± 0.41) ml/kg/min (P < 0.0001). Mean serum creatinine concentration increased from 1.26 (± 0.34) mg/dl to 2.05 (± 0.60) mg/dl (P < 0.01). Mean serum urea nitrogen concentration increased from 26.62 (± 6.83) mg/dl to a mean postthyroidectomy concentration of 34.92 (± 8.95) mg/dl (P < 0.01). All changes were significant. Two cats developed overt renal azotemia after treatment of hyperthyroidism. Our results provide further evidence that treatment of hyperthyroidism can result in impaired renal function. In addition, our results suggest that, in some instances, thyrotoxicosis might mask underlying chronic renal insufficiency.

Free access
in American Journal of Veterinary Research