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  • Author or Editor: Rosalba Tognetti x
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in Journal of the American Veterinary Medical Association

Summary

Activities of urinary α-amylase and serum macroamylase; concentrations of serum creatinine, immunocomplexes, and urinary protein; and patterns of proteinuria were determined in 35 dogs with proteinuria. Urinary α-amylase activity ranged from 37 to 4,031 U/L. Macroamylasemia was detected in 77.14% of dogs and the percentage of α-amylase precipitated ranged from 4.68 to 61.63. Serum α-amylase activity after immunoglobulin precipitation ranged from 654 to 6,390 U/L in 51.42% of the dogs; the values were higher than the reference limits. Concentrations of serum creatinine and immunocomplexes were higher than reference limits for 25.71 and 60% of dogs, respectively. Urinary protein concentrations ranged from 0.1 to 8.9 g/L· All the patterns of proteinuria were represented. Linear regression indicated correlations between urinary α-amylase activities, serum creatinine concentrations (P < 0.01), and concentration of immunocomplexes (P < 0.05). Mann-Whitney test indicated significantly higher urinary α-amylase activity (P < 0.02) and percentage of α-amylase precipitated (P < 0.05) in dogs with renal insufficiency.

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in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

Abstract

Objective—To investigate serum calcium-phosphorus concentration product (sCaPP) as a predictor of mortality rate in dogs with chronic kidney disease (CKD).

Design—Retrospective case-control study.

Animals—31 dogs with definitive CKD and 35 apparently healthy dogs.

Procedures—All dogs had been referred for nephrological consultation between December 2008 and December 2010. Dogs with CKD had stable disease for ≥ 3 months. On the basis of glomerular filtration rate < 60 mL/min/m2, 13 of the 35 apparently healthy dogs were subsequently classified as having early CKD. Disease stage among dogs was determined on the basis of plasma creatinine concentration as follows: stage 1, < 123.7 μmol/L (n = 13), stage 2, 123.7 to 176.8 μmol/L (7); stage 3, 185.6 to 442 μmol/L (13); or stage 4, > 442 μmol/L (11). For each dog, serum concentrations of ionized and total calcium and phosphorus were evaluated once; the latter 2 variables were used to determine sCaPP.

Results—The sCaPP differed significantly between the 22 healthy dogs and dogs with stage 3 or stage 4 CKD. The proportion of dogs with sCaPP > 70 mg2/dL2 increased with stage of disease. Mortality rate among the 24 dogs with sCaPP > 70 mg2/dL2 was higher than that among the 42 dogs with sCaPP ≤ 70 mg2/dL2. Dogs with sCaPP > 70 mg2/dL2 had a comparatively lower survival rate, and risk of death was 4.2 times as high as risk for dogs with sCaPP ≤ 70 mg2/dL2.

Conclusions and Clinical Relevance—For dogs with CKD, sCaPP > 70 mg2/dL2 appeared to be a negative prognostic indicator, which was not influenced by the concomitant serum concentrations of phosphorus and total or ionized calcium.

Full access
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association