Objective—To determine signalment, clinical features
of the disease, and treatment in dogs with
Animals—513 dogs with diskospondylitis (cases) and
236,109 canine hospital accessions (controls) from 12
veterinary teaching hospitals.
Procedure—Information retrieved from the medical
records of 123 dogs with diskospondylitis at the
Louisiana State University veterinary teaching hospital
between 1980 and 2001 included sex, age, breed,
primary complaint, neurologic status, location of
lesions, causative organism, treatment, and outcome.
The signalment of 390 additional cases from 11 other
veterinary teaching hospitals was accessed from the
Veterinary Medical Database. Comparisons were
made with controls from the same time periods.
Results—Male dogs were twice as likely as female
dogs to be affected (odds ratio [OR], 2.0; 95% confidence
interval [CI], 1.7 to 2.4). Dogs were significantly
more likely to be affected as age increased. Purebred
dogs, especially Great Danes, were more likely than
mixed-breed dogs to be affected (OR, 7.3; CI, 4.3
to 12.6). For dogs from Louisiana State University,
Staphylococcus spp, Brucella spp, Streptococcus spp,
and Escherichia coli were isolated most often; multiple
organisms were detected via microbial culture in 11
dogs. The mean duration of treatment was 53.7 weeks.
Conclusions and Clinical Relevance—Male dogs,
older dogs, and Great Danes appeared more likely to
be affected with diskospondylitis than female dogs,
dogs < 1 year of age, and mixed-breed dogs, respectively.
Long-term administration of antimicrobial drugs
for treatment of diskospondylitis may be expected.
Identification of the causative organism and early
treatment are recommended. (J Am Vet Med Assoc 2005;227:268–275)
Objective—To determine whether hyperbaric oxygen
treatment (HBOT) would affect incorporation of an
autogenous cancellous bone graft in diaphyseal ulnar
defects in cats.
Animals—12 mature cats.
Procedure—Bilateral nonunion diaphyseal ulnar
defects were created in each cat. An autogenous
cancellous bone graft was implanted in 1 ulnar
defect in each cat, with the contralateral ulnar
defect serving as a nongrafted specimen. Six cats
were treated by use of hyperbaric oxygen at 2
atmospheres absolute for 90 minutes once daily for
14 days, and 6 cats were not treated (control
group). Bone labeling was performed, using fluorochrome
markers. Cats were euthanatized 5
weeks after implanting, and barium sulfate was
infused to evaluate vascularization of grafts. Ulnas
were evaluated by use of radiography, microangiography,
histologic examination, and histomorphometric
Results—Radiographic scores did not differ
between treatment groups. Microangiographic
appearance of grafted defects was similar between
groups, with all having adequate vascularization.
Differences were not observed between treated
and nontreated groups in the overall histologic
appearance of decalcified samples of tissue in grafted
defects. Mean distance between fluorescent
labels was significantly greater in cats given HBOT
than in nontreated cats. Median percentage of bone
formation in grafted defects was significantly
greater in cats given HBOT.
Conclusions—Hyperbaric oxygen treatment
increased the distance between fluorescent labels
and percentage of bone formation when incorporating
autogenous cancellous bone grafts in induced
nonunion diaphyseal ulnar defects in cats, but HBOT
did not affect revascularization, radiographic appearance,
or qualitative histologic appearance of the
grafts. (Am J Vet Res 2000;61:691–698)