Objective—To assess the role of Bartonella spp in chronic rhinosinusitis (CRS) by determining detection rates for the organism by serologic testing and microbial culture of blood samples for Bartonella spp in cats with CRS and control cats (cats with other nasal diseases, cats with systemic illnesses, and healthy cats).
Design—Prospective case-control study.
Animals—19 cats with CRS, 10 cats with other nasal diseases, 15 cats with systemic illness, and 15 healthy cats.
Procedures—Serologic testing for Bartonella clarridgeiae and Bartonella henselae and microbial culture of blood samples were conducted in all cats. In cats with CRS and cats with other nasal diseases, a nasal biopsy specimen was submitted, when available, for tissue PCR assay to detect Bartonella spp.
Results—9 of 19 cats with CRS had positive results for serologic testing for 1 or both Bartonella spp; whereas, 4 of 10 cats with other nasal diseases, 2 of 15 cats with systemic diseases, and 4 of 15 healthy cats had positive results for serologic testing to detect Bartonella spp. These values did not differ significantly among groups. Microbial culture of blood samples yielded B henselae in 1 cat with a nasopharyngeal abscess. The PCR assay for Bartonella spp in nasal tissues yielded negative results for 9 of 9 cats with CRS and 5 of 5 cats with other nasal diseases.
Conclusions and Clinical Relevance—A role for Bartonella spp in the pathogenesis of CRS in cats was not supported by results of this study.
Objective—To determine the seroprevalence of antibodies
against Bartonella spp in a population of sick
dogs from northern California and identify potential
risk factors and clinical signs associated with seropositivity.
Sample Population—Sera from 3,417 dogs.
Procedure—Via an ELISA, sera were analyzed for
antibodies against Bartonella vinsonii subsp berkhoffii,
Bartonella clarridgeiae, and Bartonella henselae;
test results were used to classify dogs as seropositive
(mean optical density value ≥ 0.350 for B henselae
or ≥ 0.300 for B clarridgeiae or B vinsonii subsp
berkhoffii) or seronegative. Overall, 305 dogs (102
seropositive and 203 seronegative dogs) were included
in a matched case-control study.
Results—102 of 3,417 (2.99%) dogs were seropositive
for ≥ 1 species of Bartonella. Of these, 36 (35.3%)
had antibodies against B henselae only, 34 (33.3%)
had antibodies against B clarridgeiae only, 2 (2.0%)
had antibodies against B vinsonii subsp berkhoffiionly ,
and 30 (29.4%) had antibodies against a combination
of those antigens. Compared with seronegative dogs,
seropositive dogs were more likely to be herding dogs
and to be female, whereas toy dogs were less likely to
be seropositive. Seropositive dogs were also more
likely to be lame or have arthritis-related lameness,
nasal discharge or epistaxis, or splenomegaly.
Conclusions and Clinical Relevance—Only a small
percentage of dogs from which serum samples were
obtained had antibodies against Bartonella spp. Breed
appeared to be an important risk factor for seropositivity.
Bartonella infection should be considered in
dogs with clinical signs of lameness, arthritis-related
lameness, nasal discharge or epistaxis, or
splenomegaly. (Am J Vet Res 2005;66:688–694)