Search Results

You are looking at 1 - 7 of 7 items for

  • Author or Editor: Richard Walshaw x
  • Refine by Access: All Content x
Clear All Modify Search

Abstract

Objective—To quantify and compare intracellular magnesium concentrations (Mgi) in clinically normal dogs (control dogs) and dogs that have gastric dilatation- volvulus (GDV dogs) and to determine whether there is a difference in Mgi and serum magnesium concentrations (Mgs) between GDV dogs with and without cardiac arrhythmias.

Animals—41 control dogs and 21 GDV dogs.

Procedure—Rectus abdominis muscle specimens were obtained from control and GDV dogs for determination of Mgi. Blood samples were obtained from GDV dogs for determination of Mgs, and dogs were monitored for 48 hours for cardiac arrhythmias. Muscle specimens were frozen at –40 C, oven dried at 95 C, and digested with concentrated nitric acid. Multielemental analyses were performed by simultaneous/ sequential inductively coupled plasma-atomic emission spectroscopy with fixed-cross flow nebulization. The Mgi was standardized to sulfur content to correct for the amount of fat and fascia in the muscle specimen. Mean (± SEM) values were recorded in parts per million (ppm).

Results—There were no significant differences in Mgi between control (627 ± 11.1 ppm) and GDV (597 ± 20.5 ppm) dogs, in Mgi between GDV dogs with (590 ± 34 ppm) and without (584 ± 29 ppm) cardiac arrhythmias, and in Mgs between GDV dogs with (1.77 ± 0.26 ppm) and without (1.51 ± 0.09 ppm) cardiac arrhythmias. There was no correlation between Mgs and Mgi ( R2 =0.0001).

Conclusions and Clinical Relevance—Results indicate that Mg depletion is not pathophysiologically important in dogs with GDV and does not play a role in the cardiac arrhythmias detected in these patients. (Am J Vet Res 2000;61:1415–1417)

Full access
in American Journal of Veterinary Research

  • Anatomic changes that develop with splenic torsion, including stretching of gastric ligaments, may predispose dogs to the development of gastric dilatation-volvulus because of increased mobility of the stomach.

  • Prophylactic gastropexy at the time of splenectomy may reduce the chance of future gastric dilatation-volvulus in dogs.

Free access
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate the effects of nephrotomy on renal function in clinically normal cats.

Animals—20 specific-pathogen-free, 9- to 11-month old female mixed-breed cats.

Procedure—Serum chemistry analyses, CBC determinations, urinalyses, microbiologic urine cultures, renal ultrasonography, abdominal radiography, and single-kidney and total glomerular filtration rate (GFR) determinations by use of renal scintigraphy and measurements of plasma disappearance of technetium 99m-diethylenetriaminepentaacetic acid were performed before surgery and at 3, 12, 26, 52, and 78 weeks after surgery in 10 cats that underwent unilateral nephrotomy and in 10 control cats that underwent a sham surgical procedure.

Results—Two cats (1 from each group) did not complete the study, and their data were eliminated from analyses. Unilateral nephrotomy resulted in a 10% to 20% reduction in mean single-kidney GFR, compared with that of nephrotomy contralateral control kidneys. However, mean total GFR in nephrotomy-group cats was not significantly different from that of shamgroup cats. Over the 78 weeks of study, mean total GFR declined 34% and 40% in nephrotomy- and sham-group cats, respectively. Adverse events associated with nephrotomy included persistent microscopic hematuria, renal pelvis hyperechogenicity with distant shadowing on ultrasonographic evaluation, dilatation of renal pelves, and hydronephrosis.

Conclusions and Clinical Relevance—Nephrotomy in normal functioning feline kidneys results in a modest relative reduction in renal function, compared with contralateral kidney controls, but has minimal effect on total GFR when compared with sham-operated control cats. However, any detrimental effects of nephrotomy may be magnified in cats with diseased kidneys, which may have little or no capacity for repair or compensation. (Am J Vet Res 2005;66:1400–1407)

Full access
in American Journal of Veterinary Research

Abstract

Objective—To compare postoperative signs of discomfort and complications associated with use of CO2 laser for onychectomy with those of the scalpel technique in cats.

Design—Prospective, randomized, masked clinical trial.

Animals—20 client-owned cats.

Procedure—Forelimb feet (right, left) were randomly assigned to laser and scalpel treatment groups. Signs of discomfort (lameness and signs of pain) and complications (hemorrhage, swelling, and discharge) were assessed on days 0, 1, and 7. Surgeries were performed by 1 experienced surgeon. Evaluations were performed by 2 individuals without knowledge of treatment group. Signs of discomfort and complications were scored on scales of 0 to 8 and 0 to 9, respectively.

Results—Onychectomy did not result in high discomfort or complication scores 1 day after surgery, regardless of technique used, although the lasertreated group had significantly lower scores for signs of discomfort and complications. Seven days after surgery, significant differences were not detected between groups for signs of discomfort or complications.

Conclusions and Clinical Relevance—The CO2 laser can be an excellent tool for onychectomy in cats, with excellent hemostasis and minimal postoperative discomfort and complications. Differences in discomfort and complications between groups treated via scalpel versus CO2 laser were not clinically relevant and were only observed 1 day after surgery. (J Am Vet Med Assoc 2002;221:651–653)

Full access
in Journal of the American Veterinary Medical Association

Summary

We measured glomerular filtration rate (gfr) estimated by plasma disappearance of 99mTc-labeled diethylenetriaminepentaacetic acid, serum concentrations of thyroxine (T4), creatinine, and urea nitrogen, and urine specific gravity in 13 cats with naturally acquired hyperthyroidism before and 30 days after treatment by bilateral thyroidectomy, and in a group of 11 control cats. Mean (±sd) serum T4 concentration decreased from a pretreatment value of 120.46 (± 39.21) nmol/L to a posttreatment value of 12.15 (± 6.26) nmol/L (P < 0.0001; reference range, 10 to 48 nmol/L). Treatment of hyperthyroidism resulted in a decrease in mean (± sd) glomerular filtration rate, from 2.51 (± 0.69) ml/kg of body weight/min to a posttreatment value of 1.40 (± 0.41) ml/kg/min (P < 0.0001). Mean serum creatinine concentration increased from 1.26 (± 0.34) mg/dl to 2.05 (± 0.60) mg/dl (P < 0.01). Mean serum urea nitrogen concentration increased from 26.62 (± 6.83) mg/dl to a mean postthyroidectomy concentration of 34.92 (± 8.95) mg/dl (P < 0.01). All changes were significant. Two cats developed overt renal azotemia after treatment of hyperthyroidism. Our results provide further evidence that treatment of hyperthyroidism can result in impaired renal function. In addition, our results suggest that, in some instances, thyrotoxicosis might mask underlying chronic renal insufficiency.

Free access
in American Journal of Veterinary Research