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Objective

To determine the prevalence of various clinical signs in dogs with brain tumors.

Design

Retrospective study.

Animals

97 dogs with brain tumors.

Procedure

Medical records were reviewed for signalment, tumor type and location, and clinical signs.

Results

33 breeds were represented; Golden Retrievers were most commonly affected. Most dogs were older (median age, 9 years); 95% of dogs were ≥ 5 years old. Seventy-six percent of dogs had tumors in the supratentorial region. Seizures were the most common clinical sign at initial examination, with lower prevalence for circling, ataxia, and head tilt. Meningioma was the most common tumor.

Conclusions and Clinical Relevance

Brain tumors develop most often in dogs ≥ 5 years old and are uncommon in dogs < 5 years old. Seizures are a common clinical sign, and a brain tumor should be considered in dogs that have their first seizure after they are 4 years old. (J Am Vet Med Assoc 1999;215:818–819)

Free access
in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

To determine whether ABCB11930_1931del TC predisposed cats to macrocyclic-lactone toxicosis and the frequency of the ABCB11930_1931del TC gene mutation in banked feline DNA samples.

SAMPLE

DNA samples from 5 cats presented for neurologic clinical signs presumed to be caused by exposure to macrocyclic lactones and 1,006 banked feline DNA samples.

PROCEDURES

The medical history pertaining to 5 cats was obtained from veterinarians who examined, treated, or performed necropsies on them. The DNA from these 5 cats and 1,006 banked feline samples were analyzed for the presence of the ABCB11930_1931del TC genotype.

RESULTS

4 of the 5 cats with neurologic signs presumed to be associated with macro-cyclic-lactone exposure were homozygous for ABCB11930_1931del TC. The other cat had unilateral vestibular signs not typical of macrocyclic-lactone toxicosis. The distribution of genotypes from the banked feline DNA samples was as follows: 0 homozygous for ABCB11930_1931del TC, 47 heterozygous for ABCB11930_1931del TC, and 959 homozygous for the wild-type ABCB1 allele. Among the 47 cats with the mutant ABCB1 allele, only 3 were purebred (Ragdoll, Russian Blue, and Siamese).

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested a strong relationship between homozygosity for ABCB11930_1931del TC and neurologic toxicosis after topical application with eprinomectin-containing antiparasitic products labeled for use in cats. Although this genotype is likely rare in the general cat population, veterinarians should be aware of this genetic mutation in cats and its potential for enhancing susceptibility to adverse drug reactions. (J Am Vet Med Assoc 2021;259:72–76)

Full access
in Journal of the American Veterinary Medical Association