A 15-year-old 18.3-kg (40.3-lb) spayed female mixed-breed dog was referred for treatment of stage V multicentric B-cell lymphosarcoma. Lymphoma of the spleen was diagnosed by means of microscopic examination of a fine-needle aspirate sample; detection of circulating malignant lymphocytes in peripheral blood was suggestive of bone marrow involvement. Chemotherapy with the University of Wisconsin-Madison protocol1 was initiated in February 2012. The dog responded well to chemotherapy and had been in remission since commencement of chemotherapy.
On physical examination at the time that chemotherapy was initiated, the dog's body condition was considered normal (body condition score, 5/9). Mild tachypnea
Objective—To compare induction and recovery characteristics and cardiopulmonary effects of isoflurane and sevoflurane in bald eagles.
Animals—17 healthy adult bald eagles.
Procedures—Anesthesia was induced with isoflurane or sevoflurane delivered in oxygen via a facemask in a crossover design with 4 weeks between treatments. Eagles were intubated, allowed to breathe spontaneously, and instrumented for cardiopulmonary measurements. Time to induction, extubation, and recovery, as well as smoothness of recovery, were recorded.
Results—Administration of sevoflurane resulted in a significantly quicker recovery, compared with isoflurane. Temperature, heart rate, and respiratory rate significantly decreased over time, whereas systolic (SAP), diastolic (DAP), and mean arterial blood pressure (MAP) significantly increased over time with each treatment. Temperature, heart rate, SAP, DAP, and MAP were significantly higher with isoflurane. Blood pH significantly decreased, whereas PaCO2 significantly increased over time with each treatment. Bicarbonate and total carbon dioxide concentrations significantly increased over time with each treatment; however, there was a significant time-treatment interaction. The PaO2 and arterial oxygen saturation increased over time with isoflurane and decreased over time with sevoflurane with a significant time-treatment interaction. Six eagles developed cardiac arrhythmias with isoflurane, as did 4 with sevoflurane anesthesia.
Conclusions and Clinical Relevance—Isoflurane and sevoflurane administration resulted in smooth, rapid induction of and recovery from anesthesia similar to other species. Isoflurane administration resulted in tachycardia, hypertension, and more arrhythmias, compared with sevoflurane. Sevoflurane was associated with fewer adverse effects and may be particularly beneficial in compromised bald eagles.