A 3-year-old sexually intact male mink at a mink farm was found dead and submitted for necropsy. There was no history of prior illness.
Clinical and Gross Findings
Because of the absence of signs of illness, no clinical tests had been performed prior to necropsy. The mink was slightly thin and mildly dehydrated. It had severe periodontal disease, and all 4 canine teeth were broken. The pleural cavity was filled with thick, yellow to brown, creamy fluid (Figure 1). The pulmonary pleural and pericardial surfaces were tan, granular, and proliferative.
A male foal had difficulty nursing during the first 24 hours after birth and was bottle fed. It also had difficulty passing meconium. The foal's condition seemed to improve during the next day. On the morning of the third day, the foal was observed nursing; however, in the afternoon of that day, the foal became weak, could not rise, began flailing, and was mentally dull. Late that evening, the referring veterinarian administered fluids and dextrose solution IV but the foal did not respond. It died a few hours later at 4 days of age.
A 6-year-old 29.9-kg (65.8-lb) castrated male Golden Retriever was evaluated because of weight loss, weakness, and inappetence, all of 1 month's duration, as well as vomiting and diarrhea of 2 weeks’ duration.
Clinical and Gross Findings
On physical examination at the referral clinic, the dog had signs of depression and was slightly dehydrated. Clinicopathologic analyses revealed mild leukocytosis (16,700 WBCs/µL; reference interval, 4,000 to 15,500 WBCs/μL) characterized by mild neutrophilia (13,527 neutrophils/µL; reference interval, 2,060 to 10,600 neutrophils/µL) and mild monocytosis (1,670 monocytes/μL; reference interval, 0 to 840 monocytes/µL). Hyperproteinemia (8.1 g/dL; reference interval, 5.0 to 7.4 g/dL), hyperglobulinemia
Ten 18-week-old female laying chickens were submitted for necropsy following an outbreak of severe respiratory tract disease that was associated with open-mouthed breathing in affected members of the flock. Five of the birds were found dead, and the other 5 birds had no apparent clinical signs and were submitted live and euthanized with CO2 just prior to necropsy. The chickens were from a flock of 40,000 birds. The 5 dead chickens were among 2,022 birds in the flock that had died within a 2-week period (5.1% death loss in 2 weeks) in April 2011; acceptable death loss
An approximately 9-year-old neutered male mixed-breed dog was evaluated at the Michigan State University Veterinary Teaching Hospital because of an ulcerated mass on the rostral aspect of the mandible. The mass was first noted approximately 3 months prior and had been surgically debulked twice. Recurrence of the mass was rapid after each surgery. Three years before the evaluation, the dog had a hepatocellular carcinoma (mixed solid and pelioid) that was incompletely resected. At that time, the dog underwent 4 cycles of chemotherapy (gemcitabine and carboplatin administered IV). At the evaluation, the dog did not have any clinical signs that
An approximately 2-month-old 31.8-kg (70-lb) castrated male feeder pig that died was submitted for necropsy examination at the Diagnostic Center for Population and Animal Health at Michigan State University. The pig was raised on a farm for which porcine circovirus type 2 (PCV-2) infection had been reported in the 2 years before the pig's death; pigs on the farm had received appropriate vaccines since that time. Recently, a group of feeder pigs became ill; the producer suggested the illness was possibly due to heat stress.
The pig was in fair nutritional condition (body condition score, 2 [scale,
A 4-year-old neutered male Treeing Walker Coonhound was evaluated because of a 4-month history of chronic signs of back pain and progressing paraparesis. On initial evaluation, the dog was weak in the pelvic limbs and swayed to the left side. Severe muscle atrophy of the pelvic limbs was evident. Signs of pain were elicited on palpation of the caudal lumbar region. Conscious proprioception was fully present in the left pelvic limb but was slightly decreased in the right pelvic limb. The pelvic limbs had hypertonic reflexes, and the dog dribbled urine both while lying down and standing. The tail
To determine the frequency of previously reported coding variants in the ATP7A, ATP7B, and RETN genes in a US population of Labrador Retrievers and to explore potential associations of these genotypes with pathologic hepatic copper accumulation.
Archived hepatic specimens from 90 Labrador Retrievers collected between 2013 and 2021.
The Michigan State University Veterinary Diagnostic Laboratory database was searched to identify archived tissues from Labrador Retrievers that had undergone hepatic histopathologic assessment. Cases were classified into control, copper-associated hepatopathy (CAH), and intermediate populations on the basis of histopathologic features and hepatic copper accumulation. The DNA was extracted from archived tissues and genotyped for reported variants in the 3 genes. Allele frequencies were determined, and associations of genotypes with CAH status were evaluated.
29 control dogs, 45 CAH dogs, and 16 intermediate dogs were included in the study. The overall ATP7A and RETN variant allele frequencies were 30% and 13%, respectively, and were not significantly different among control, CAH, and intermediate populations. The ATP7B variant allele frequency was significantly higher in the CAH population (30%) as compared to the control population (13%). However, 21 of 45 (47%) CAH dogs did not have an ATP7B variant allele whereas 7 of 28 (25%) control dogs did have an ATP7B variant allele.
Study results supported a contributory role for the ATP7B variant in CAH pathogenesis in Labrador Retrievers. However, the application of genetic testing in a clinical setting is complicated by genotypic variability within healthy and diseased dogs.