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  • Author or Editor: Randall J. Itkin x
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Summary

Effective renal plasma flow (erpf) was evaluated, using the measurement of p-aminohippurate clearance (cl pah ) and quantitative renal scintigraphy (qrs) with 99mTc-mercaptoacetyltriglycine (99mTc-MAG3). The cl pah and qrs determinations were made in 6 dogs: 2 determinations for each dog before, and 1 determination after induction of renal failure by administration of amphotericin B. Least-squares regression analysis was used to derive an equation to estimate erpf from qrs data. The results indicated that qrs, using 99mTc-MAG3, correlated reasonably well (r = 0.82, P < 0.001) with erpf determined from the cl pah value. The right kidney contributed 53.3% of global erpf (P = 0.002). Hepatobiliary excretion of 99mTc-MAG3 was variable within each dog. There was not a consistent pattern with respect to time or renal function. All dogs had nausea or emesis, or both, after iv administration of 99mTc-MAG3. The qrs method with 99mTc-MAG3 provides an adequate means to estimate erpf in healthy dogs and dogs with renal failure.

Free access
in American Journal of Veterinary Research

Summary

Effective renal plasma flow (erpf) was evaluated, using continuous-infusion p-aminohippurate clearance (cl pah ) and single-injection plasma clearance of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3; cl mag3) methods. Simultaneous clearance determinations were made in 6 dogs: 2 determinations for each dog before, and 1 determination after renal failure was induced by administration of amphotericin B. Linear regression analysis was used to derive an equation to estimate erpf from cl mag3 after the single iv injection. A Student’s t-test was used to compare pharmacokinetics between the dogs when they were healthy and when they were in renal failure. An F-test was used to determine the appropriate Student’s t-test. Results indicated that cl mag3 correlated reasonably well (r = 0.83, P < 0.0001) with erpf obtained from the cl pah value. The volume of distribution and elimination of 99mTc-MAG3 decreased during renal failure. Although there was minimal binding of 99mTc-MAG3 to erythrocytes, it was significantly (P = 0.0008) lower during renal failure. Protein binding was not significantly different during renal failure. All dogs had signs of nausea and emesis at variable times after injection of 99mTc-MAG3. Determination of cl mag3 after a single injection provides an adequate means to rapidly assess erpf in dogs. The technique could easily be performed in dogs with renal disease, thus providing valuable information regarding progression of naturally acquired renal failure.

Free access
in American Journal of Veterinary Research

Objective

To evaluate efficacy and nephrotoxicity of amphotericin B lipid complex used for treatment of dogs with naturally developing blastomycosis.

Design

Prospective clinical trial.

Animals

11 dogs with blastomycosis.

Procedure

All dogs were treated with an amphotericin B lipid complex. Two dogs received a cumulative dose of 8 mg/kg of body weight, 1 received a cumulative dose of 10 mg/kg, and 8 received a cumulative dose of 12 mg/kg.

Results

The 2 dogs that received a cumulative dose of 8 mg/kg and 1 of the dogs that received a cumulative dose of 12 mg/kg had a relapse of blastomycosis within 30 days after treatment. Seven of the remaining 8 dogs were clinically free of blastomycosis 6 months after treatment. One dog died of an unrelated cause 5.5 months after treatment, but did not have clinical signs of blastomycosis at the time of death. There were not any adverse clinical effects attributable to drug administration in any of the dogs in this study, and none of the dogs developed clinical signs of renal disease or failure.

Clinical Implications

Amphotericin B lipid complex was a safe and effective treatment for blastomycosis in these dogs. (J Am Vet Med Assoc 1996;209:2073–2075)

Free access
in Journal of the American Veterinary Medical Association