To evaluate dogs with total hypercalcemia, azotemia, and normal serum phosphorus concentrations to determine whether a calcium-to-phosphorus ratio (Ca:P) or ionized Ca:P (iCa:P) could be utilized to predict underlying neoplasia.
105 dogs were included in the study. Thirty-seven percent (n = 39) had known neoplasia, and 63% (66) had no evidence of neoplasia.
A retrospective medical records search was performed. An observational cutoff of 2.5 for Ca:P and 0.33 for iCa:P was used for determining sensitivity and specificity between the neoplasia and nonneoplasia groups.
Total hypercalcemia was higher in dogs with neoplasia compared to nonneoplastic cases of hypercalcemia. Ca:P of 2.5 had an 80% sensitivity and 46% specificity for predicting neoplasia. iCa:P of 0.33 had a 92% sensitivity and 77% specificity for predicting neoplasia in azotemic dogs.
The sensitivity and specificity of Ca:P was low, making it an unreliable tool to predict neoplasia in this specific study population. However, iCa:P may have some usefulness in determining presence of neoplasia in patients with high calcium, azotemia, and normal phosphorus.
Objective—To evaluate intestinal permeability and
gluten sensitivity in a family of Soft-Coated Wheaten
Terriers (SCWT) affected with protein-losing
enteropathy (PLE), protein-losing nephropathy (PLN),
Animals—6 affected adult dogs.
Procedure—Intestinal biopsy specimens, urine protein-
to-creatinine ratio, serum concentrations of albumin
and globulin, and concentration of α1-protease
inhibitor in feces were evaluated before, during, and
13 weeks after daily administration of 10 g of gluten
for 7 weeks. Eosinophils and lymphocytes-plasmacytes
were enumerated in intestinal biopsy specimens.
Intestinal permeability was evaluated before
and during the sixth week of gluten administration via
cellobiose-mannitol and chromium-EDTA absorption
Results—Serum globulin concentration decreased significantly
after prolonged administration of gluten.
Although not significant, there was an increase in lymphocytes-
plasmacytes and a decrease in eosinophils in
intestinal biopsy specimens. Furthermore, these counts
were greater than those reported for clinically normal
dogs. Gluten administration did not increase intestinal
Conclusions and Clinical Relevance—Daily administration
of gluten was associated with a significant
decrease in serum globulin concentration in SCWT
affected with PLE or PLN, but other variables
remained unchanged. Although enhanced wheatgluten
sensitivity may be one factor involved in the
pathogenesis of PLE or PLN in SCWT, this syndrome
does not appear to be the result of a specific sensitivity
to gluten. (Am J Vet Res 2000;61:518–524)