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Abstract

Objective

To study a combined urodynamic technique for assessment of urethral closure and bladder storage function in female dogs.

Animals

20 healthy, adult, sexually intact female dogs of various breeds.

Procedure

Urethral pressure profilometry and continuous urethral pressure registration during high-diuresis cystometry (cysto-urethrometry) were studied in dogs sedated with xylazine. Pressures were measured, using a flexible polyvinylchloride multichannel catheter connected to a perfusion system. Urine production and volume were determined by radionucleotide dilution analysis of urine samples. Urethral pressure profilometry was performed first, followed by cystourethrometry. Maximal urethral pressure and maximal urethral closure pressure of consecutive profiles and their mean values were determined. Closure pressure at its highest and lowest level and at micturition threshold and absolute and relative magnitude of urethral pressure variation were determined in the high-pressure zone of the urethra while the bladder filled, enforced by diuresis. Bladder pressure and volume at the micturition threshold and static compliance also were determined.

Results

Differences in mean and variance between variables listed were not significant. Urethral closure pressure varied from 5 to 67 cm of H2O during bladder storage. So-called unstable detrusor contractions were observed in 6 dogs.

Conclusions

Several variables for the assessment of the dynamics of urethral closure and bladder storage function obtained by the technique reported here are reproducible. Values from this study are considered reference values for further studies.

Clinical Relevance

The reported technique can be helpful in the investigation of complicated urinary incontinence in female dogs. (Am J Vet Res 1996;57:1131-1136)

Free access
in American Journal of Veterinary Research

Abstract

Objective

To assess urethral closure and bladder storage function in female dogs with refractory urinary incontinence by use of simultaneous diuresis cysto-urethrometry (UCM) and multi-channel urethral pressure profilometry (UPP).

Animals

53 female dogs of various breeds with a history of ‘non-neurogenic,’ acquired urinary incontinence unresponsive to standard conservative treatment.

Procedure

UPP and UCM were performed on dogs sedated with xylazine, using a flexible polyvinylchloride multi-channel catheter connected to a perfusion system. Urine production was determined by use of radionucleotide dilution analysis. Values of reproducible urodynamic variables obtained previously in clinically normal dogs were compared with findings in the incontinent dogs. Cutoff values with the highest predictive values of urodynamic variables were determined and selected for functional classification.

Results

Except for threshold volume, median values of all urodynamic variables were significantly different between continent and incontinent dogs. Urethral pressure values, their relative variation, bladder threshold pressure, and prevalence of detrusor contractions were significantly lower than values in normal dogs, but compliance was higher. Forty-one dogs had urodynamic findings suggestive of poor urethral closure function assessed by UCM, but 10 of these had normal closure pressure values during UPP. Abnormal bladder storage function was interpreted from the findings of 19 dogs. Low capacity was found in 3, low threshold pressure in 15, and high compliance in 9 dogs. Seven of the dogs with abnormal bladder storage function had normal urethral closure function assessed by UPP and UCM. Five dogs had no abnormal findings, and 1 continent dog was abnormal by our classification.

Conclusions

Abnormal bladder storage function was suggested in a considerable number of dogs with refractory urinary incontinence. (Am J Vet Res 1997;58:691–696)

Free access
in American Journal of Veterinary Research