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  • Author or Editor: R. Keith Harris x
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Abstract

Objective—To evaluate expression of cyclooxygenase (COX)-1 and COX-2 in the urinary bladder epithelium of clinically normal dogs and in transitional cell carcinoma cells of dogs.

Animals—21 dogs with transitional cell carcinoma of the urinary bladder and 8 dogs with clinically normal urinary bladders.

Procedure—COX-1 and COX-2 were evaluated by use of isoform-specific antibodies with standard immunohistochemical methods.

Results—COX-1, but not COX-2, was constitutively expressed in normal urinary bladder epithelium; however, COX-2 was expressed in neoplastic epithelium in primary tumors and in metastatic lesions of all 21 dogs and in new proliferating blood vessels in 3 dogs. Also, COX-1 was expressed in the neoplastic cells.

Conclusions and Clinical Relevance—Lack of expression of COX-2 in normal bladder epithelium and its substantial expression in transitional cell carcinoma cells suggest that this isoform may be involved in tumor cell growth. Inhibition of COX-2 is a likely mechanism of the antineoplastic effects of non steroidal antiinflammatory drugs. (Am J Vet Res 2000;61:478–481)

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in American Journal of Veterinary Research
History

An 8-year-old 43-kg (94.6-lb) castrated male Labrador Retriever was evaluated at the University of Georgia Veterinary Teaching Hospital because of stranguria of 4 days’ duration. The dog was only able to expel a few drops of urine after straining for a prolonged time, although the urine produced was normal in appearance. The dog had no other notable medical history.

Clinical and Gross Findings

When the dog was first presented to the referring veterinarian, no abnormalities were identified on physical examination, and the results of routine hematologic and serum biochemical analyses were unremarkable. A urinary catheter was placed to allow

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in Journal of the American Veterinary Medical Association