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  • Author or Editor: R. F. Bevill x
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Summary

Plasma catecholamine concentrations in response to onychectomy were examined in 27 cats receiving different anesthetic regimens. Each cat was anesthetized with a dissociative-tranquilizer combination, and onychectomy was performed on 1 forefoot. One week later, each cat was anesthetized with the same dissociative-tranquilizer combination plus either butorphanol or oxymorphone, and onychectomy was performed on the other forefoot. Four treatment groups were studied: tiletamine-zolazepam and tiletamine-zolazepam-butorphanol combinations were administered to group-1 cats, ketamine-acepromazine and ketamine-acepromazine-butorphanol combinations were administered to group-2 cats, tiletamine-zolazepam and tiletamine-zolazepam-oxymorphone combinations were administered to group-3 cats, and ketamine-acepromazine and ketamine-acepromazine-oxymorphone combinations were administered to group-4 cats. All drug combinations were administered im. Central venous blood samples were drawn for catecholamine analysis after injection of drug(s), after onychectomy, and 1, 2, and 4 hours after injection. Tiletamine-zolazepam alone or tiletamine-zolazepam-butorphanol prevented epinephrine release for 2 hours after injection of drug(s). Norepinephrine concentration increased significantly (P < 0.05) from baseline after onychectomy for tiletamine-zolazepam-butorphanol and at 4 hours for tiletamine-zolazepam and tiletamine-zolazepam-butorphanol. After onychectomy, there was no difference in epinephrine values between tiletamine-zolazepam and tiletamine-zolazepam-oxymorphone. Ketamine-acepromazine prevented increases in norepinephrine and epinephrine concentrations for up to 2 hours after surgery. Addition of butorphanol to ketamine-acepromazine decreased norepinephrine values immediately after onychectomy. Addition of oxymorphone to ketamine-acepromazine resulted in lower epinephrine values 4 hours after surgery.

Free access
in American Journal of Veterinary Research

SUMMARY

Sodium salicylate was administered to cattle and goats iv and po according to a crossover design. Total urinary excretion of sa and its metabolites was measured for 3 days after dosing. Salicyluric acid (sua) was the only metabolite detected in urine of either species. Recovery of sodium salicylate and sua in goats amounted to 67.9 and 34.6% of the dose, respectively, after iv administration. After oral dosing, total recoveries were 30.2% (sodium salicylate) and 71.7%(sua) of dose. By comparison, cattle excreted significantly (P < 0.05) less sodium salicylate (54.0%) and more sua (49.9%) after iv dosing. The same pattern was observed after oral administration, wherein cattle excreted < 12% as sodium salicylate and more than 99% as sua. In both species, almost 90% of the drug excreted as sodium salicylate was found in urine within the first 12 hours after an iv dose and within 24 hours after oral dosing. The excretion of sua was somewhat slower in both species, especially after oral administration. The data suggested that there were only quantitative differences in the metabolism and elimination of sodium salicylate between the 2 species, with cattle excreting a higher proportion of the drug as the glycine conjugate sua.

Free access
in American Journal of Veterinary Research