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- Author or Editor: Pia Funkquist x
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Abstract
Objective—To image the spatial distribution of pulmonary blood flow by means of scintigraphy, evaluate ventilation-perfusion (VA/Q) matching and pulmonary blood shunting (Qs/Qt) by means of the multiple inert gas elimination technique (MIGET), and measure arterial oxygenation and plasma endothelin-1 concentrations before, during, and after pulse-delivered inhaled nitric oxide (PiNO) administration to isoflurane-anesthetized horses in dorsal recumbency.
Animals—3 healthy adult Standardbreds.
Procedures—Nitric oxide was pulsed into the inspired gases in dorsally recumbent isoflurane-anesthetized horses. Assessment of VA/Q matching, Qs/Qt, and Pao 2 content was performed by use of the MIGET, and spatial distribution of pulmonary blood flow was measured by perfusion scintigraphy following IV injection of technetium Tc 99m–labeled macroaggregated human albumin before, during, and 30 minutes after cessation of PiNO administration.
Results—During PiNO administration, significant redistribution of blood flow from the dependent regions to the nondependent regions of the lungs was found and was reflected by improvements in VA/Q matching, decreases in Qs/Qt, and increases in Pao 2 content, all of which reverted to baseline values at 30 minutes after PiNO administration.
Conclusions and Clinical Relevance—Administration of PiNO in anesthetized dorsally recumbent horses resulted in redistribution of pulmonary blood flow from dependent atelectatic lung regions to nondependent aerated lung regions. Because hypoxemia is commonly the result of atelectasis in anesthetized dorsally recumbent horses, the addition of nitric oxide to inhaled gases could be used clinically to alleviate hypoxemia in horses during anesthesia.
Objective—
To evaluate use of propofol-isoflurane as an anesthetic regimen for cesarean section in dogs and to compare this protocol with epidural analgesia and anesthesia induced with thiopental sodium.
Design—
Prospective study.
Animals—
141 bitches admitted for cesarean section.
Procedure—
General anesthesia was induced with propofol in 141 dogs undergoing cesarean section. After intubation, anesthesia was maintained by means of inhalation of isoflurane (0.5 to 2.0%), administered in a 65:35 mixture of oxygen:nitrous oxide. After induction, 20 minutes were allowed to elapse before delivery of puppies was begun. Viability of neonates was ascertained immediately after surgery. Owners were interviewed by telephone to determine survival of puppies during the postoperative period. Survival rates from this study were compared with those from cesarean section performed on dogs under epidural analgesia or under general anesthesia induced with thiopental sodium.
Results—
Induction, maintenance, and recovery were problem free in all bitches. Of 412 puppies delivered by cesarean section, 293 (71%) survived, 13 (3%) were born alive but died within 20 minutes of delivery, and 106 (26%) were stillborn. Survival rate for puppies from dams induced with propofol-isoflurane was similar to that for puppies from dams receiving epidural analgesia. Survival rate for puppies delivered by cesarean section performed on dams under general anesthesia was higher for dams induced with propofol than for dams induced with thiopental sodium.
Clinical Implications—
General anesthesia induced with propofol and maintained with isoflurane is acceptable for performing cesarean section in dogs,. (J Am Vet Med Assoc 1997;211:313–317)