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in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
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Summary

The Virginia-Maryland Regional College of Veterinary Medicine responded to the Pew-sponsored National Veterinary Education Program by proposing a Center for Government and Corporate Veterinary Medicine. The Center is currently providing, through elective course offerings and practical experiences, a senior clinical curriculum that permits career emphasis in a number of species areas, in addition to a unique program for graduates wishing to enter the field of public and corporate veterinary medicine. The Center is also developing post-veterinary school education for advanced degrees (PhD, MS) and residency training in public and corporate fields, and for midcareer updating and changes of career emphasis.

Free access
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

Summary

The relation between average duodenal mast cell count, duodenal mucosal mast cell numbers, duodenal connective tissue mast cell numbers, circulating basophil numbers, heterophil-to-lymphocyte ratio, and lesion score were studied to gain an understanding of the events that may lead to intestinal lesion formation associated with hemorrhagic enteritis virus (hev) infection. Changes in vascular permeability in the duodenum in birds inoculated with hev were examined, using colloidal carbon and ferritin as vascular markers. Turkeys inoculated with hev had significantly (P < 0.05) higher duodenal mast cell counts than did noninfected controls. Birds inoculated with hev had significantly (P < 0.05) more mucosal mast cells than did phosphate-buffered saline solution-inoculated birds. Connective tissue mast cell and basophil numbers were unaffected by viral inoculation. Thermal stress did not have significant effect on lesion severity, but did increase number of birds that developed the characteristic intestinal lesions. The heterophil-to-lymphocyte ratio was significantly (P < 0.05) higher in hev-inoculated birds, compared with phosphate-buffered saline solution-inoculated controls. Increase in vascular permeability was only detected in hev-inoculated birds with intestinal lesions. Results indicate that mast cells, and the vasoactive mediators contained within mast cells, may be important in the early manifestation of hev infection. They also provide a possible mechanism through which biochemical and physiologic changes characteristic of hev infection can occur.

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in American Journal of Veterinary Research
in Journal of the American Veterinary Medical Association

Summary

The relative myocardial irritant properties of halothane, isoflurane, and pentobarbital were evaluated in chickens. Sixteen adult male broiler chickens were randomly assigned to 1 of 3 groups: group-1 chickens were anesthetized with pentobarbital (30 mg/kg, iv), group-2 chickens were anesthetized with halothane (end tidal halothane 1.2%), and group-3 chickens were anesthetized with isoflurane (end tidal isoflurane 2.1%). Birds in any 2 of the 3 treatment groups were tested on any 1 day. Local anesthesia was induced, and blood pressure, heart rate, ecg, and blood gas variables were measured before general anesthesia was induced. Positive-pressure ventilation with an inspired O2 fraction > 0.95 was adjusted to result in an end tidal CO2 concentration that reflected a PaCO2 similar to that obtained prior to anesthesia and ventilation. All measurements were repeated. The threshold for ventricular fibrillation in response to electrical stimulation of the heart was then determined for all birds. Effects of anesthesia on hemodynamic and blood gas variables were similar in all 3 groups. Compared with halothane or pentobarbital, isoflurane anesthesia resulted in a significantly (P < 0.05) lower threshold for electrical fibrillation of the heart.

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in American Journal of Veterinary Research