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Abstract

In collaboration with the American College of Veterinary Radiology

Open access
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association

Objective—

To evaluate use of fluprostenol, dexamethasone, and oxytocin for induction of parturition in alpacas, and to determine viability of the newborn crias.

Design—

Prospective, randomized, controlled trial.

Animals—

36 pregnant alpacas within 10 days of parturition.

Procedure—

Animals were randomly assigned to treatment groups. Plasma progesterone and plasma and urine estrone sulfate concentrations were measured for 5 days after treatment. Clinical signs of the neonates were determined.

Results—

Time between treatment and parturition was significantly shorter for animals that received fluprostenol than for animals in any other group. The highest dose of dexamethasone (0.5 mg) caused fetal death. None of the other treatments induced early parturition. Time between birth and first suckling, body weight, rectal temperature, pulse rate, and respiratory rate at birth and serum IgG concentration 24 hours after birth were not different between crias born after fluprostenol treatment and crias born to control alpacas.

Clinical Implications—

Fluprostenol was effective at inducing parturition in these alpacas, but dexamethasone and oxytocin were not. crias born after fluprostenol treatment were similar to crias born to control alpacas. (J Am Vet Med Assoc 1996;209:1760–1762)

Free access
in Journal of the American Veterinary Medical Association

Abstract

Objective—To determine whether measurement of blood cardiac troponin I (cTnI) concentrations with a cage-side analyzer could be used to differentiate cardiac from noncardiac causes of dyspnea in cats.

Design—Prospective, multicenter study.

Animals—44 client-owned cats with dyspnea and 37 healthy staff-owned cats.

Procedures—Affected cats were examined because of dyspnea; treatment was administered in accordance with the attending clinician's discretion. Cats were judged to have a cardiac or noncardiac cause of dyspnea on the basis of results of physical examination, thoracic radiography, and echocardiography. Blood cTnI concentrations were determined with a cage-side analyzer on samples collected within 12 hours after admission of affected cats. Concentrations for healthy cats were obtained for comparison.

Results—5 enrolled cats were excluded from the study because of concurrent cardiac and respiratory disease. Of the remaining 39 cats with dyspnea, 25 had a cardiac cause and 14 had a noncardiac cause. The 25 cats with a cardiac cause of dyspnea had a significantly higher blood cTnI concentration than did the 37 healthy cats or the 14 cats with a noncardiac cause of dyspnea.

Conclusions and Clinical Relevance—Measurement of cTnI concentrations with a cage-side assay in emergency settings may be useful for differentiating cardiac from noncardiac causes of dyspnea in cats.

Full access
in Journal of the American Veterinary Medical Association

Abstract

Objective

To determine the potential clinical usefulness of duplex Doppler estimation of arcuate artery resistive index (a measure of intrarenal blood flow impedance) for diagnosis of aminoglycoside-induced nephrotoxicosis.

Animals

30 adult, female, mixed-breed dogs, allotted to 3 groups of 10 dogs each as: toxic dosage of gentamicin, therapeutic dosage of gentamicin, and saline solution sham equivalent in volume to that of the toxic dosage of gentamicin.

Procedure

After baseline screening to establish normalcy (serum biochemical analysis, endogenous creatinine clearance determination, urinalysis, urine protein-to-creatinine ratio, urine culture, gray-scale sonography, and percutaneous ultrasound-guided renal biopsy), results of arcuate artery resistive index determination were compared with serum creatinine and urine specific gravity values on a Monday-Wednesday-Friday data collection schedule for 10 days. Endogenous creatinine clearance determination, ultrasound-guided renal biopsy, and urine culture were repeated at the end of data collection in all 3 groups.

Results

Significant differences in resistive index measurements were not observed, despite clinicopathologic and renal biopsy results compatible with severe acute tubular necrosis in dogs of the toxic dosage group.

Conclusions

Duplex Doppler sonography of arcuate artery blood flow impedance, expressed as the resistive index, appears to have poor clinical usefulness as a diagnostic tool in this disorder.

Clinical Relevance

Normal arcuate artery resistive index values obtained in dogs for which aminoglycoside-induced nephrotoxicosis is suspected do not exclude the disorder. If abnormal arcuate artery resistive index values are obtained for such dogs, further evaluation for nephropathies other than aminoglycoside-induced nephrotoxi-cosis may be considered. (Am J Vet Res 1996;57:1536–1544)

Free access
in American Journal of Veterinary Research