Objective—To determine clinical and radiographic
features of subchondral cystic lesions (SCL) of the
proximal extremity of the tibia in horses that could be
used to classify these lesions as being related to
osteochondrosis or osteoarthritis and to evaluate
results of surgical debridement.
Animals—12 horses with 14 SCL.
Procedure—Medical records and radiographs
obtained before and after treatment were reviewed.
Results—In 6 young horses (8 lesions), SCL were considered
to be related to osteochondrosis; all involved
the lateral tibial condyle. The remaining 6 horses were
mature and had radiographic evidence of osteoarthritis
in addition to SCL. Arthroscopic debridement was performed
in 4 horses in which lesions were considered to
be a result of osteochondrosis and in 3 horses with
osteoarthritis. Three horses in which SCL were considered
to be a result of osteochondrosis performed athletically
after debridement. Two horses with moderate
osteoarthritis returned to work after arthroscopic
debridement but at a lower level of athletic performance.
One horse with SCL related to osteochondrosis
responded to medical treatment and went on to race.
Conclusions and Clinical Relevance—Results suggest
that arthroscopic debridement of SCL is feasible
in horses in which lesions involve the cranial portion
of the lateral or medial tibial condyle, and that treated
horses may be able to perform athletically. (J Am Vet
Med Assoc 2001;218:408–413)
Objective—To evaluate whether administering a tart cherry juice blend (TCJB) prior to exercise would reduce skeletal and cardiac muscle damage by decreasing the inflammatory and oxidative stress response to exercise in horses.
Procedures—Horses were randomly allocated into 2 groups in a crossover study with a 2-week washout period and orally administered either TCJB or a placebo solution (1.42 L, twice daily) in a double-masked protocol for 2 weeks prior to a stepwise incremental exercise protocol. Horses were tested for serum activities of creatine kinase and aspartate aminotransferase (AST) and concentrations of cardiac troponin I (cTnI), thiobarbituric acid reactive substances (TBARS; an indicator of oxidative stress), and serum amyloid A (SAA; an indicator of inflammation). To ensure that treatment would not result in positive results of an equine drug-screening protocol, serum samples obtained from each horse prior to and after 2 weeks of administration of TCJB or the placebo solution were tested.
Results—All horses had negative results of drug screening at both sample times. The exercise protocol resulted in a significant increase in TBARS concentration, SAA concentration, and serum AST activity in all horses. Administration of TCJB or placebo solution was not associated with an effect on malondialdehyde or SAA concentrations. However, administration of TCJB was associated with less serum activity of AST, compared with administration of placebo solution.
Conclusions and Clinical Relevance—Administration of TCJB may diminish muscle damage induced by exercise.