Objective—To assess the intraoperative and postoperative clinical effects and histologic effects of intracameral administration of α-chymotrypsin in clinically normal dogs undergoing standard intracapsular lens extraction (ICLE).
Animals—6 young adult male dogs without evidence of systemic or ocular disease.
Procedures—All dogs underwent bilateral ICLE 7 minutes following injection of 75 U of α-chymotrypsin or an identical volume (0.5 mL) of a commercially available balanced saline solution (BSS) into the posterior chamber of the eye. Ease of lens extraction was subjectively assessed and intraoperative intraocular hemorrhage and fibrin accumulation scored. For 27 days after surgery, ocular hyperemia and discharge, chemosis, corneal edema, hyphema, and aqueous flare were scored, and intraocular pressure (IOP) was measured. Thirty days after surgery, histologic evidence of anterior synechia, collapse of and inflammation within the iridocorneal angle, and iritis were scored.
Results—In 5 of 6 dogs, the surgeon was able to correctly identify the eye treated with α-chymotrypsin on the basis of ease of lens extraction. Mean intraoperative intraocular hemorrhage and fibrin scores for BSS-treated eyes were significantly higher than for α-chymotrypsin-treated eyes. Postoperatively, there were no significant differences between treatments for any clinical variables, including IOP Histologic scores were not significantly different between treatments for any variable. Vision was lost as a result of glaucoma in 1 α-chymotrypsin-treated eye and 1 BSS-treated eye.
Conclusions and Clinical Relevance—Intracameral administration of 75 U of α-chymotrypsin 7 minutes before ICLE facilitated lensectomy without apparent adverse effects in clinically normal dogs.
Objective—To identify complications associated with
tibial plateau leveling osteotomy (TPLO) for treatment
of cranial cruciate ligament rupture in dogs and
assess owner perceptions of outcome.
Animals—193 dogs that underwent unilateral or
bilateral TPLO (253 TPLOs total) between November
1997 and March 2001.
Procedure—Complications associated with the surgical
procedure were recorded. A questionnaire was
sent to owners of all dogs to assess their perceptions
Results—Complications were identified in 47 of the
193 (24.4%) dogs and in association with 52 of the
253 (20.6%) TPLOs. Dogs that underwent bilateral
TPLOs during a single anesthetic episode had a higher
complication rate than did dogs that underwent
unilateral TPLO and dogs that underwent bilateral
TPLOs during separate anesthetic episodes. Body
weight, surgery time, whether a meniscal release or
meniscectomy was performed, and extent of cruciate
ligament damage were not associated with whether
complications occurred. One hundred forty-one of
151 (93%) owners who responded to the questionnaire
were satisfied with the outcome of the surgery.
Assessments of outcome were not significantly different
between owners of dogs that had complications
and owners of dogs that did not.
Conclusions and Clinical Relevance—Results indicated
that complications developed in approximately 25%
of dogs undergoing TPLO for treatment of a cranial cruciate
ligament injury but that most complications
responded to appropriate treatment, and development
of complications did not affect owner assessments of
outcome. There was a higher incidence of complications
when bilateral TPLOs were performed during a
single anesthetic episode. (J Am Vet Med Assoc 2003;