Objective—To compare myocardial concentrations of
fatty acids in dogs with dilated cardiomyopathy (DCM)
with concentrations in control dogs.
Sample Population—Myocardial tissues from 7
dogs with DCM and 16 control dogs.
Procedure—Myocardial tissues were homogenized,
and total fatty acids were extracted and converted to
methyl esters. Myocardial concentrations of fatty
acids were analyzed by use of gas chromatography
and reported as corrected percentages.
Results—The amount of docosatetraenoic acid
(C22:4 n-6) was significantly higher in myocardial samples
from dogs with DCM (range, 0.223% to 0.774%;
median, 0.451%), compared with the amount in samples
obtained from control dogs (range, 0.166% to
0.621%; median, 0.280%). There were no significant
differences between DCM and control dogs for concentrations
of any other myocardial fatty acids.
Conclusions and Clinical Relevance—Although concentrations
of most myocardial fatty acids did not differ
significantly between dogs with DCM and control
dogs, the concentration of docosatetraenoic acid was
significantly higher in dogs with DCM. Additional
investigation in a larger population is warranted to
determine whether this is a primary or secondary
effect of the underlying disease and whether alterations
in fatty acids may be a target for intervention in
dogs with DCM. (Am J Vet Res 2005;66:1483–1486)