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in Journal of the American Veterinary Medical Association
History

A 15-week-old 14.1-kg (31-lb) male yellow Labrador Retriever was referred to the Neurology and Neurosurgery service at The Ohio State University because of dullness, lethargy, and a right-sided head tilt that progressively worsened over a period of several weeks.

Clinical and Gross Findings

Results of the clinical neurologic examination were consistent with a central vestibular lesion. Abnormalities included dull mentation, intermittent opisthotonic posture and lateral recumbency, absent menace response in both eyes, decreased oculocephalic reflex in both eyes, bilateral decreased nasal sensation, and spontaneous vertical nystagmus in both eyes. Magnetic resonance imaging of the brain revealed a large, well-demarcated,

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To determine analgesic effects of intraneural injection of ethyl alcohol or formaldehyde in the palmar digital nerves of horses.

Animals—6 horses.

Procedures—Ethyl alcohol was injected in the medial palmar digital nerve of 1 forelimb, and formaldehyde was injected in the contralateral nerve. The lateral palmar digital nerve in 1 forelimb was surgically exposed, but not injected, and the contralateral lateral palmar digital nerve was not treated. For each heel, severity of lameness in response to experimentally induced heel pain (lameness score and peak vertical force), thermal reaction time, and heel skin sensitivity scores were recorded. Heel pain was experimentally induced by advancing a threaded bolt through a custom-made horseshoe to apply pressure to the palmar horned aspect of the hoof. Horses were followed up for 112 days, when a subset of nerves was sampled for histologic analysis.

Results—Alcohol and formaldehyde significantly reduced all measures of heel pain, and analgesia was evident over the 112 days of the study. Pastern circumference was significantly greater for formaldehyde-treated than for alcohol-treated limbs. Histologic evaluation showed preservation of nerve fiber alignment with an intact epineurium, loss of axons, axon degeneration, fibrosis, and inflammation in alcohol-treated and formaldehyde-treated nerves.

Conclusions and Clinical Relevance—Results suggested that intraneural injection of either ethyl alcohol or formaldehyde in the palmar digital nerves of horses resulted in substantial, but partial, heel analgesia that persisted for at least 112 days. No advantage of formaldehyde over alcohol was found, and formaldehyde resulted in greater soft tissue inflammation.

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in American Journal of Veterinary Research