Objective—To evaluate the correlation between halftime
of liquid-phase gastric emptying (T50), determined
with nuclear scintigraphy using technetium
Tc 99m pentetate, and absorption variables of orally
Animals—6 mature horses.
Procedure—Technetium Tc 99m pentetate (10 mCi)
and acetaminophen (20 mg/kg of body weight) were
administered simultaneously in 200 ml of water. Serial
left and right lateral images of the stomach region
were obtained with a gamma camera, and T50 determined
separately for counts obtained from the left
side, the right side and the geometric mean. Power
exponential curves were used for estimation of T50
and modified R2 values for estimation of goodness of
fit of the data. Serial serum samples were taken, and
acetaminophen concentration was determined, using
fluorescence polarization immunoassay. Maximum
serum concentration (Cmax), time to reach maximum
serum concentration (Tmax), area under the curve for
240 minutes and the absorption constant (Ka) were
determined, using a parameter estimation program.
Correlations were calculated, using the Spearman
rank correlation coefficient.
Results—Correlations between T50 and Tmax and
between T50 and Ka were significant.
Conclusions and Clinical Relevance—Tmax and Ka
are valuable variables in the assessment of liquidphase
gastric emptying using acetaminophen absorption.
Acetaminophen absorption may be a valuable
alternative to nuclear scintigraphy in the determination
of gastric emptying rates in equine patients with
normally functioning small intestine. (Am J Vet Res
Objective—To evaluate the association between spondylosis deformans and clinical signs of intervertebral disk disease (IVDD) in dogs.
Design—Retrospective case series.
Procedure—Records of 172 dogs with clinical signs of IVDD and 38 dogs with other neurologic disorders were reviewed. Signalment, sites of spondylosis, severity of associated osteophytosis, type of disk herniation, and duration of signs were recorded.
Results—Dogs with IVDD had significantly fewer sites of involvement and lower grades of spondylosis deformans, compared with those in the non-IVDD group. When groups were adjusted for age and weight via multivariate linear regression, there were no differences in severity of osteophytosis or number of affected sites. Dogs with type II disk disease had higher numbers of affected sites and more severe changes, compared with dogs with type I disk herniation. There was no difference between groups in the rate at which IVDD was diagnosed at sites of spondylosis, compared with the rate at which IVDD was diagnosed in unaffected disk spaces. Areas of spondylosis were closer to sites of IVDD that elicited clinical signs than to randomly chosen intervertebral spaces, and distances between sites of spondylosis and sites of IVDD had a bimodal appearance.
Conclusions and Clinical Relevance—An association may exist between radiographically apparent spondylosis and type II disk disease; type I disk disease was not associated with spondylosis. Spondylosis in radiographs of dogs with suspected type I disk disease is not clinically important. Spatial associations among sites of spondylosis and sites of IVDD may be coincidental or associated with vertebral column biomechanics.