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  • Author or Editor: Matthew Corse x
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Abstract

Objective—To conduct an in vitro investigation of the biomechanical characteristics of the canine lumbar spinal column in flexion and extension and measure the destabilizing effects of multiple consecutive unilateral and bilateral hemilaminectomies.

Sample Population—30 isolated multisegmental spinal units (L1-L4) from nonhypochondroplastic dogs weighing 15 to 30 kg.

Procedure—Physically normal and surgically altered spinal specimens were subjected to 4-point bending in flexion and extension to determine effects of multiple consecutive hemilaminectomies on the basis of analysis of test system load-displacement data. Six groups with 5 spinal columns in each were defined on the basis of the following procedures: hemilaminectomy at L2-L3, 2 adjacent hemilaminectomies at L1- L3, 3 adjacent hemilaminectomies at L1-L4, bilateral hemilaminectomies at L2-L3, 2 bilateral hemilaminectomies at L1-L3, and no hemilaminectomy (intact). Spinal stability before and after surgery was determined in all groups. Each group served as its own control for nondestructive testing. Spinal strength was evaluated through destructive testing to determine deformation at failure, strength to failure, and mode of catastrophic failure. The intact group served as the control for destructive testing.

Results—Stability in extreme flexion and extreme extension did not change significantly following any hemilaminectomy procedure. Postoperative stability within the neutral zone was significantly decreased in all groups. Range of motion within the neutral zone was not significantly different from the intact condition in any group.

Conclusions and Clinical Relevance—Multiple hemilaminectomies did not decrease stiffness of the lumbar spinal column during flexion and extension. These results support clinical recommendations regarding multiple consecutive hemilaminectomies in dogs. (Am J Vet Res 2003;64:1139–1145)

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in American Journal of Veterinary Research

Abstract

Objective—To determine the plasma pharmacokinetics and synovial fluid concentrations after oral administration of single and multiple doses of celecoxib in Greyhounds.

Animals—7 adult Greyhounds.

Procedure—Dogs received celecoxib (median dose, 11.8 mg/kg [range, 11.5 to 13.6 mg/kg], PO, q 24 h) for 10 days. Blood samples were collected prior to administration of celecoxib and serially for 24 hours after the 1st and 10th doses were administered. A synovial joint catheter was placed into a stifle joint in each dog for collection of synovial fluid samples. Concentrations of celecoxib in plasma and synovial fluid were quantified by use of a validated liquid chromatography/mass spectrometry method. Identification of hydroxy- and carboxyl-celecoxib in plasma and synovial fluid was also performed. Pharmacokinetic parameters were determined by use of noncompartmental analysis.

Results—Administration of multiple doses of celecoxib resulted in a significant decrease (40%) in median area under the curve (AUC) values and a corresponding decrease in median maximum concentrations (Cmax; 2,620 to 2,032 ng/mL) between the 1st and 10th doses. Synovial fluid concentrations were less than the corresponding plasma concentrations at all times except 24 hours after administration of the 10th dose of celecoxib.

Conclusions and Clinical Relevance—Celecoxib distributes into the synovial fluid of Greyhounds. Although the exact mechanism for the decreases in AUC and Cmax is not known, results suggested that the plasma pharmacokinetics of celecoxib are different after administration of multiple doses in Greyhounds. These findings warrant further investigation on the absorption, distribution, metabolism, and elimination of celecoxib in Greyhounds and other breeds of dogs. (Am J Vet Res 2005;66:1441–1445)

Full access
in American Journal of Veterinary Research