Objective—To characterize urodynamic function and
anatomy before and after colposuspension in anesthetized
Animals—12 adult female Beagles.
Procedure—During general anesthesia (thiopental
sodium induction and halothane maintenance), urethral
pressure profiles, leak point pressure measurements
with a 50-ml bladder volume, positive contrast
cystograms, and retrograde vaginourethrocystograms
were performed. A caudal midline laparotomy was
used to perform colposuspension. Urodynamic and
radiographic studies were repeated after surgery.
Results—Leak point pressures were increased (120
to 168.9 cm H2O), and maximum urethral closure
pressures decreased (43.7 to 19.3 cm H2O ) after colposuspension.
The urethra and bladder were moved
cranially; the external urethral orifice was positioned
closer to the pelvic cavity, and the neck of the bladder
was positioned more cranially into the abdomen.
Length of the urethra, as measured by use of vaginourethrocystograms,
was increased by 3%. As measured
by use of urethral pressure profiles, total profile
length was increased by 19.9%, and functional profile
length was increased by 19.2%.
Conclusions and Clinical Relevance—Increased
leak-point pressure correlated with the expected clinical
improvement attributable to colposuspension.
Increased exposure of the urethra to abdominal and
pelvic cavity pressures may be the mechanism by
which incontinent dogs become continent after colposuspension.
Results of the leak-point pressure test
may correlate with clinical behavior before and after
colposuspension for treatment of incontinence. (Am J
Vet Res 2000;61:1353–1357)