Objective—To assess whether serum canine parvovirus
(CPV) and canine distemper virus (CDV) antibody
titers can be used to determine revaccination
protocols in healthy dogs.
Animals—1,441 dogs between 6 weeks and 17 years
Procedure—CPV and CDV antibody titers in serum
samples submitted to a commercial diagnostic laboratory
were measured by use of indirect fluorescent
antibody (IFA) tests. On the basis of parallel measurements
of CPV and CDV serum antibody titers in 61
paired serum samples determined by use of hemagglutination
inhibition and serum neutralization methods,
respectively, we considered titers ≥ 1:5 (IFA test)
indicative of an adequate antibody response.
Results—Age, breed, and sex were not significantly
associated with adequate CPV- or CDV-specific antibody
responses. Of 1,441 dogs, 1,370 (95.1%) had
adequate and 71 (4.9%) had inadequate antibody
responses to CPV, whereas 1,346 of 1,379 (97.6%)
dogs had adequate and 33 (2.4%) had inadequate
responses to CDV. Vaccination histories were available
for 468 dogs (468 for CPV, 457 for CDV). Interval
between last vaccination and antibody measurement
was 1 to 2 years for the majority (281/468; 60.0%) of
dogs and 2 to 7 years for 142 of 468 (30.3%) dogs.
Interval was < 1 year in only 45 of 468 (9.6%) dogs.
Conclusion and Clinical Relevance—The high
prevalence of adequate antibody responses (CPV,
95.1%; CDV, 97.6%) in this large population of dogs
suggests that annual revaccination against CPV and
CDV may not be necessary. (J Am Vet Med Assoc